DegronMD

Uniprot ID: Q9H2G2

Source protein: STE20-like serine/threonine-protein kinase

Source gene: SLK

Class: DEG_APCC_DBOX_1

Location: 426:434

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9857

ASA_SCORE: 104.8667

COIL: 0.7338

CONS_SCORE: 0.2869

DSS_SCORE: 0.6384

HELIX: 0.2519

FCONS_SCORE: 1.0499

RIG_SCORE: 0.6814

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K429T	TCGA-AA-A010	COAD	TCGA	KRPKLENLP	DEG_APCC_DBOX_1	0.6195
p.E437D	TCGA-B5-A0JY	UCEC	TCGA	KRPKLENLP	DEG_APCC_DBOX_1	0.25
p.E437D	DO43041	UCEC	ICGC	KRPKLENLP	DEG_APCC_DBOX_1	0.25
p.I444N	DO52656	MALY	ICGC	KRPKLENLP	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_APCC_DBOX_1	426:434	KRPKLENLP	APC,CDC20,FZR1	0.9857	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons