DegronMD

Uniprot ID: Q9H2G2

Source protein: STE20-like serine/threonine-protein kinase

Source gene: SLK

Class: DEG_Kelch_Keap1_1

Location: 716:721

E3 ligase: KEAP1

DEGRON score: 0.9696

ASA_SCORE: 88

COIL: 0.8797

CONS_SCORE: 0.2696

DSS_SCORE: 0.586

HELIX: 0.1003

FCONS_SCORE: 0.9774

RIG_SCORE: 0.6218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K723E	TCGA-DD-A3A9	LIHC	TCGA	NSDSGE	DEG_Kelch_Keap1_1	0.2778
p.K723E	DO44888	LIHC	ICGC	NSDSGE	DEG_Kelch_Keap1_1	0.2778
p.L709V	TCGA-DK-A3IS	BLCA	TCGA	NSDSGE	DEG_Kelch_Keap1_1	0.1389
p.L709V	DO566	BLCA	ICGC	NSDSGE	DEG_Kelch_Keap1_1	0.1389
p.G727S	TCGA-GL-6846	KIRP	TCGA	NSDSGE	DEG_Kelch_Keap1_1	0.1667
p.G727S	DO20808	KIRP	ICGC	NSDSGE	DEG_Kelch_Keap1_1	0.1667
p.S728Y	SIDM01611	Endometrial Carcinoma	GDSC	NSDSGE	DEG_Kelch_Keap1_1	0.5833
p.S728Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	NSDSGE	DEG_Kelch_Keap1_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_Kelch_Keap1_1	716:721	NSDSGE	KEAP1	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons