DegronMD

Uniprot ID: Q9H2G2

Source protein: STE20-like serine/threonine-protein kinase

Source gene: SLK

Class: DEG_SCF_TRCP1_1

Location: 749:755

E3 ligase: BTRC

DEGRON score: 0.9721

ASA_SCORE: 76.5429

COIL: 0.9073

CONS_SCORE: 0.3062

DSS_SCORE: 0.6914

HELIX: 0.062

FCONS_SCORE: 1.0502

RIG_SCORE: 0.5723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D749G	TCGA-D9-A6EC	SKCM	TCGA	DSGTGST	DEG_SCF_TRCP1_1	0.7198
p.D749G	DO50291	SKCM	ICGC	DSGTGST	DEG_SCF_TRCP1_1	0.7198
p.E741D	TCGA-EO-A3AV	UCEC	TCGA	DSGTGST	DEG_SCF_TRCP1_1	0.1111
p.E741D	DO52412	UCEC	ICGC	DSGTGST	DEG_SCF_TRCP1_1	0.1111
p.S750L	TCGA-FI-A2EY	UCEC	TCGA	DSGTGST	DEG_SCF_TRCP1_1	0.7667
p.S750L	DO40984	UCEC	ICGC	DSGTGST	DEG_SCF_TRCP1_1	0.7667
p.N748H	SIDM00935	Other Solid Cancers	GDSC	DSGTGST	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_SCF_TRCP1_1	749:755	DSGTGST	BTRC	0.9721	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons