DegronMD

Uniprot ID: Q9H2G2

Source protein: STE20-like serine/threonine-protein kinase

Source gene: SLK

Class: DEG_APCC_DBOX_1

Location: 1067:1075

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8701

ASA_SCORE: 101.2333

COIL: 0.2791

CONS_SCORE: 0.4677

DSS_SCORE: 0.6227

HELIX: 0.7078

FCONS_SCORE: 1.0846

RIG_SCORE: 0.7449

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1060F	TCGA-69-7980	LUAD	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	0.1389
p.L1060F	DO23678	LUAD	ICGC	ERARLPKIQ	DEG_APCC_DBOX_1	0.1389
p.E1058K	TCGA-A2-A0SY	BRCA	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	0.0833
p.E1058K	DO2961	BRCA	ICGC	ERARLPKIQ	DEG_APCC_DBOX_1	0.0833
p.E1078D	TCGA-FI-A2D5	UCEC	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	0.25
p.E1078D	DO41331	UCEC	ICGC	ERARLPKIQ	DEG_APCC_DBOX_1	0.25
p.R1082Q	TCGA-IB-7651	PAAD	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	0.1389
p.R1082Q	DO46657	PAAD	ICGC	ERARLPKIQ	DEG_APCC_DBOX_1	0.1389
p.R1082Q	ACH-000928	Endometrial/Uterine Cancer	CCLE	ERARLPKIQ	DEG_APCC_DBOX_1	0.1389
p.T1065I	TCGA-OR-A5LE	ACC	TCGA	ERARLPKIQ	DEG_APCC_DBOX_1	0.2778
p.A1084D	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ERARLPKIQ	DEG_APCC_DBOX_1	0.0833
p.A1084D	ACH-001669	Leukemia	CCLE	ERARLPKIQ	DEG_APCC_DBOX_1	0.0833
p.A1084D	ACH-002238	Leukemia	CCLE	ERARLPKIQ	DEG_APCC_DBOX_1	0.0833
p.A1084D	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	ERARLPKIQ	DEG_APCC_DBOX_1	0.0833
p.R1076C	SIDM00193	Colorectal Carcinoma	GDSC	ERARLPKIQ	DEG_APCC_DBOX_1	0.3056
p.R1076C	ACH-000991	Colon/Colorectal Cancer	CCLE	ERARLPKIQ	DEG_APCC_DBOX_1	0.3056
p.R1076C	SNU-81	large_intestine	COSMIC	ERARLPKIQ	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_APCC_DBOX_1	1067:1075	ERARLPKIQ	APC,CDC20,FZR1	0.8701	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons