DegronMD

Uniprot ID: Q9H2G2

Source protein: STE20-like serine/threonine-protein kinase

Source gene: SLK

Class: DEG_APCC_DBOX_1

Location: 827:835

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.658

ASA_SCORE: 106.7111

COIL: 0.0783

CONS_SCORE: 0.4589

DSS_SCORE: 0.2375

HELIX: 0.9221

FCONS_SCORE: 1.188

RIG_SCORE: 0.8331

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R828H	TCGA-EA-A3HS	CESC	TCGA	RRQELRELR	DEG_APCC_DBOX_1	0.8244
p.R828H	DO6260	CESC	ICGC	RRQELRELR	DEG_APCC_DBOX_1	0.8244
p.R832W	SIDM01588	Endometrial Carcinoma	GDSC	RRQELRELR	DEG_APCC_DBOX_1	0.7523
p.R832W	ACH-000993	Endometrial/Uterine Cancer	CCLE	RRQELRELR	DEG_APCC_DBOX_1	0.7523
p.L837F	TCGA-EE-A20C	SKCM	TCGA	RRQELRELR	DEG_APCC_DBOX_1	0.2778
p.L837F	DO222775	MELA	ICGC	RRQELRELR	DEG_APCC_DBOX_1	0.2778
p.L837F	DO47665	SKCM	ICGC	RRQELRELR	DEG_APCC_DBOX_1	0.2778
p.R824W	TCGA-BR-8361	STAD	TCGA	RRQELRELR	DEG_APCC_DBOX_1	0.25
p.R824W	DO222445	BTCA	ICGC	RRQELRELR	DEG_APCC_DBOX_1	0.25
p.R824W	DO233254	GACA	ICGC	RRQELRELR	DEG_APCC_DBOX_1	0.25
p.R824W	DO48032	STAD	ICGC	RRQELRELR	DEG_APCC_DBOX_1	0.25
p.L823F	DO229234	THCA	ICGC	RRQELRELR	DEG_APCC_DBOX_1	0.2222
p.E821K	SIDM00101	Mesothelioma	GDSC	RRQELRELR	DEG_APCC_DBOX_1	0.1667
p.A844S	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	RRQELRELR	DEG_APCC_DBOX_1	0.0833
p.A844S	ACH-000925	Lung Cancer	CCLE	RRQELRELR	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_APCC_DBOX_1	827:835	RRQELRELR	APC,CDC20,FZR1	0.658	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons