DegronMD

Uniprot ID: Q9H2G2

Source protein: STE20-like serine/threonine-protein kinase

Source gene: SLK

Class: DEG_APCC_KENBOX_2

Location: 450:454

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 104.32

COIL: 0.7796

CONS_SCORE: 0.2917

DSS_SCORE: 0.4834

HELIX: 0.1604

FCONS_SCORE: 1.0499

RIG_SCORE: 0.6969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I457L	TCGA-4R-AA8I	LIHC	TCGA	GKENN	DEG_APCC_KENBOX_2	0.25
p.I457L	DO49657	LIHC	ICGC	GKENN	DEG_APCC_KENBOX_2	0.25
p.N454Y	TCGA-BH-A0DK	BRCA	TCGA	GKENN	DEG_APCC_KENBOX_2	0.5948
p.N454Y	DO1305	BRCA	ICGC	GKENN	DEG_APCC_KENBOX_2	0.5948
p.M456T	TCGA-BS-A0UJ	UCEC	TCGA	GKENN	DEG_APCC_KENBOX_2	0.2778
p.M456T	DO42745	UCEC	ICGC	GKENN	DEG_APCC_KENBOX_2	0.2778
p.I444N	DO52656	MALY	ICGC	GKENN	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3YBR2	Transforming growth factor beta regulator 1	DEG_APCC_KENBOX_2	144:148	GKENN	APC,CDC20,FZR1	0.8614	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_APCC_KENBOX_2	450:454	GKENN	APC,CDC20,FZR1	0.995	More...
Q5HYR2	Doublesex- and mab-3-related transcription factor C1	DEG_APCC_KENBOX_2	23:27	GKENN	APC,CDC20,FZR1	0.5204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons