DegronMD

Uniprot ID: Q3YBR2

Source protein: Transforming growth factor beta regulator 1

Source gene: TBRG1

Class: DEG_APCC_KENBOX_2

Location: 144:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8614

ASA_SCORE: 99.12

COIL: 0.6236

CONS_SCORE: 0.5557

DSS_SCORE: 0.5469

HELIX: 0.3632

FCONS_SCORE: 1.0227

RIG_SCORE: 0.6834

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L150M	TCGA-AP-A051	UCEC	TCGA	GKENN	DEG_APCC_KENBOX_2	0.2778
p.L150M	DO42673	UCEC	ICGC	GKENN	DEG_APCC_KENBOX_2	0.2778
p.K145N	TCGA-DF-A2KN	UCEC	TCGA	GKENN	DEG_APCC_KENBOX_2	0.6918
p.K145N	DO223282	UCEC	ICGC	GKENN	DEG_APCC_KENBOX_2	0.6918
p.C157R	TCGA-JX-A3Q8	CESC	TCGA	GKENN	DEG_APCC_KENBOX_2	0.0833
p.C157R	DO51608	CESC	ICGC	GKENN	DEG_APCC_KENBOX_2	0.0833
p.K140R	DO230334	COCA	ICGC	GKENN	DEG_APCC_KENBOX_2	0.3333
p.C157S	ACH-000037	Sarcoma	CCLE	GKENN	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3YBR2	Transforming growth factor beta regulator 1	DEG_APCC_KENBOX_2	144:148	GKENN	APC,CDC20,FZR1	0.8614	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_APCC_KENBOX_2	450:454	GKENN	APC,CDC20,FZR1	0.995	More...
Q5HYR2	Doublesex- and mab-3-related transcription factor C1	DEG_APCC_KENBOX_2	23:27	GKENN	APC,CDC20,FZR1	0.5204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons