DegronMD

Uniprot ID: Q5HYR2

Source protein: Doublesex- and mab-3-related transcription factor C1

Source gene: DMRTC1; DMRTC1B

Class: DEG_APCC_KENBOX_2

Location: 23:27

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5204

ASA_SCORE: 89.6

COIL: 0.7508

CONS_SCORE: 0.6695

DSS_SCORE: 0.5109

HELIX: 0.138

FCONS_SCORE: 1.0084

RIG_SCORE: 0.7014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G23V	TCGA-97-A4M0	LUAD	TCGA	GKENN	DEG_APCC_KENBOX_2	0.6421
p.G23V	DO218935	LUAD	ICGC	GKENN	DEG_APCC_KENBOX_2	0.6421
p.K24N	TCGA-AJ-A3EK	UCEC	TCGA	GKENN	DEG_APCC_KENBOX_2	0.6918
p.K24N	DO41584	UCEC	ICGC	GKENN	DEG_APCC_KENBOX_2	0.6918
p.R17K	DO228664	LICA	ICGC	GKENN	DEG_APCC_KENBOX_2	0.1667
p.R17K	DO228664	LICA	ICGC	GKENN	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3YBR2	Transforming growth factor beta regulator 1	DEG_APCC_KENBOX_2	144:148	GKENN	APC,CDC20,FZR1	0.8614	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_APCC_KENBOX_2	450:454	GKENN	APC,CDC20,FZR1	0.995	More...
Q5HYR2	Doublesex- and mab-3-related transcription factor C1	DEG_APCC_KENBOX_2	23:27	GKENN	APC,CDC20,FZR1	0.5204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons