DegronMD

Uniprot ID: Q9H2G2

Source protein: STE20-like serine/threonine-protein kinase

Source gene: SLK

Class: DEG_Kelch_Keap1_1

Location: 503:508

E3 ligase: KEAP1

DEGRON score: 0.9945

ASA_SCORE: 95.95

COIL: 0.6703

CONS_SCORE: 0.2941

DSS_SCORE: 0.4275

HELIX: 0.2778

FCONS_SCORE: 1.0799

RIG_SCORE: 0.7363

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E505D	TCGA-AX-A2HC	UCEC	TCGA	SQETGE	DEG_Kelch_Keap1_1	0.5647
p.E505D	DO41572	UCEC	ICGC	SQETGE	DEG_Kelch_Keap1_1	0.5647
p.Q504K	TCGA-KQ-A41N	BLCA	TCGA	SQETGE	DEG_Kelch_Keap1_1	0.5833
p.Q504K	DO223588	BLCA	ICGC	SQETGE	DEG_Kelch_Keap1_1	0.5833
p.D493N	DO222762	COCA	ICGC	SQETGE	DEG_Kelch_Keap1_1	0.0556
p.D517V	DO231593	LINC	ICGC	SQETGE	DEG_Kelch_Keap1_1	0.0833
p.T506A	DO23186	LINC	ICGC	SQETGE	DEG_Kelch_Keap1_1	0.825
p.D493G	SIDM01770	Gastric Carcinoma	GDSC	SQETGE	DEG_Kelch_Keap1_1	0.0556
p.D493G	ACH-000908	Gastric Cancer	CCLE	SQETGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_Kelch_Keap1_1	503:508	SQETGE	KEAP1	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons