DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ADTSS
Uniprot ID:
Q9H2G2
Source protein:
STE20-like serine/threonine-protein kinase
Source gene:
SLK
Class:
DEG_SPOP_SBC_1
Location:
756:760
E3 ligase:
SPOP
DEGRON score:
0.982
ASA_SCORE:
80.84
COIL:
0.8056
CONS_SCORE:
0.2872
DSS_SCORE:
0.5365
HELIX:
0.1542
FCONS_SCORE:
0.9287
RIG_SCORE:
0.7165
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A756S
DO229026
LICA
ICGC
ADTSS
DEG_SPOP_SBC_1
0.7588
p.N748H
SIDM00935
Other Solid Cancers
GDSC
ADTSS
DEG_SPOP_SBC_1
0.1111
Drug responses associated with SLK mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ADTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P23759
Paired box protein Pax-7
DEG_SPOP_SBC_1
346:350
ADTSS
SPOP
0.5936
More...
P35125
Ubiquitin carboxyl-terminal hydrolase 6
DEG_SPOP_SBC_1
1386:1390
ADTSS
SPOP
0.8488
More...
P49750
YLP motif-containing protein 1
DEG_SPOP_SBC_1
867:871
ADTSS
SPOP
0.9941
More...
Q13796
Protein Shroom2
DEG_SPOP_SBC_1
227:231
ADTSS
SPOP
0.9912
More...
Q6T4R5
Nance-Horan syndrome protein
DEG_SPOP_SBC_1
771:775
ADTSS
SPOP
0.8619
More...
Q6UVM3
Potassium channel subfamily T member 2
DEG_SPOP_SBC_1
636:640
ADTSS
SPOP
0.9248
More...
Q7Z417
Nuclear fragile X mental retardation-interacting protein 2
DEG_SPOP_SBC_1
604:608
ADTSS
SPOP
0.9979
More...
Q8NFA0
Ubiquitin carboxyl-terminal hydrolase 32
DEG_SPOP_SBC_1
1584:1588
ADTSS
SPOP
0.6823
More...
Q96KM6
Zinc finger protein 512B
DEG_SPOP_SBC_1
382:386
ADTSS
SPOP
0.9081
More...
Q99708
DNA endonuclease RBBP8
DEG_SPOP_SBC_1
14:18
ADTSS
SPOP
0.8958
More...
Q9BYW2
Histone-lysine N-methyltransferase SETD2
DEG_SPOP_SBC_1
2460:2464
ADTSS
SPOP
0.8672
More...
Q9H2G2
STE20-like serine/threonine-protein kinase
DEG_SPOP_SBC_1
756:760
ADTSS
SPOP
0.982
More...
Q9Y3R5
Protein dopey-2
DEG_SPOP_SBC_1
1113:1117
ADTSS
SPOP
0.995
More...
Q9Y613
FH1/FH2 domain-containing protein 1
DEG_SPOP_SBC_1
430:434
ADTSS
SPOP
0.8521
More...
Q6ZMY6
WD repeat-containing protein 88
DEG_SPOP_SBC_1
449:453
ADTSS
SPOP
0.5826
More...