DegronMD

Uniprot ID: Q6ZMY6

Source protein: WD repeat-containing protein 88

Source gene: WDR88

Class: DEG_SPOP_SBC_1

Location: 449:453

E3 ligase: SPOP

DEGRON score: 0.5826

ASA_SCORE: 54.48

COIL: 0.8754

CONS_SCORE: 0.5434

DSS_SCORE: 0.6312

HELIX: 0.0396

FCONS_SCORE: 0.9631

RIG_SCORE: 0.6129

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R441Q	TCGA-D6-A6EP	HNSC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1111
p.R441Q	TCGA-E6-A2P9	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1111
p.R441Q	DO52084	HNSC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.R441Q	DO43714	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.R441Q	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.R441Q	ACH-002220	Lymphoma	CCLE	ADTSS	DEG_SPOP_SBC_1	0.1111
p.R441Q	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.N462K	DO233736	GACA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.0833
p.G446V	DO229028	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.25
p.C440F	DO229034	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.0833
p.A449T	DO34448	PACA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.7139
p.R441W	SIDM01154	T-Lymphoblastic Leukemia	GDSC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.R441W	ACH-000953	Leukemia	CCLE	ADTSS	DEG_SPOP_SBC_1	0.1111
p.R441W	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.T451I	SIDM00217	Colorectal Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.7078
p.T451I	SNU-1040	large_intestine	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.7078
p.E461K	ACH-002509	Skin Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23759	Paired box protein Pax-7	DEG_SPOP_SBC_1	346:350	ADTSS	SPOP	0.5936	More...
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_SPOP_SBC_1	1386:1390	ADTSS	SPOP	0.8488	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	867:871	ADTSS	SPOP	0.9941	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	227:231	ADTSS	SPOP	0.9912	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	771:775	ADTSS	SPOP	0.8619	More...
Q6UVM3	Potassium channel subfamily T member 2	DEG_SPOP_SBC_1	636:640	ADTSS	SPOP	0.9248	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	604:608	ADTSS	SPOP	0.9979	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_SPOP_SBC_1	1584:1588	ADTSS	SPOP	0.6823	More...
Q96KM6	Zinc finger protein 512B	DEG_SPOP_SBC_1	382:386	ADTSS	SPOP	0.9081	More...
Q99708	DNA endonuclease RBBP8	DEG_SPOP_SBC_1	14:18	ADTSS	SPOP	0.8958	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	2460:2464	ADTSS	SPOP	0.8672	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_SPOP_SBC_1	756:760	ADTSS	SPOP	0.982	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1113:1117	ADTSS	SPOP	0.995	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	430:434	ADTSS	SPOP	0.8521	More...
Q6ZMY6	WD repeat-containing protein 88	DEG_SPOP_SBC_1	449:453	ADTSS	SPOP	0.5826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons