DegronMD

Uniprot ID: Q9BYW2

Source protein: Histone-lysine N-methyltransferase SETD2

Source gene: SETD2

Class: DEG_SPOP_SBC_1

Location: 2460:2464

E3 ligase: SPOP

DEGRON score: 0.8672

ASA_SCORE: 75.74

COIL: 0.5216

CONS_SCORE: 0.4621

DSS_SCORE: 0.5588

HELIX: 0.4854

FCONS_SCORE: 1.0783

RIG_SCORE: 0.693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2470I	TCGA-12-0707	GBM	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1667
p.S2470I	DO12634	GBM	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1667
p.E2472K	TCGA-AA-3984	COAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1111
p.E2472K	DO9002	COAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.S2452L	TCGA-AD-6548	COAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1111
p.S2452L	TCGA-B5-A11E	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1111
p.S2452L	DO9586	COAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.S2452L	DO41644	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.A2460V	TCGA-AM-5821	COAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.5825
p.A2460V	DO8240	COAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.5825
p.S2463Y	TCGA-CA-6717	COAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.712
p.S2463Y	DO8264	COAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.712
p.K2453N	SIDM00534	Colorectal Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.25
p.K2453N	ACH-000986	Colon/Colorectal Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.25
p.K2453N	HT-115	large_intestine	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23759	Paired box protein Pax-7	DEG_SPOP_SBC_1	346:350	ADTSS	SPOP	0.5936	More...
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_SPOP_SBC_1	1386:1390	ADTSS	SPOP	0.8488	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	867:871	ADTSS	SPOP	0.9941	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	227:231	ADTSS	SPOP	0.9912	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	771:775	ADTSS	SPOP	0.8619	More...
Q6UVM3	Potassium channel subfamily T member 2	DEG_SPOP_SBC_1	636:640	ADTSS	SPOP	0.9248	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	604:608	ADTSS	SPOP	0.9979	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_SPOP_SBC_1	1584:1588	ADTSS	SPOP	0.6823	More...
Q96KM6	Zinc finger protein 512B	DEG_SPOP_SBC_1	382:386	ADTSS	SPOP	0.9081	More...
Q99708	DNA endonuclease RBBP8	DEG_SPOP_SBC_1	14:18	ADTSS	SPOP	0.8958	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	2460:2464	ADTSS	SPOP	0.8672	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_SPOP_SBC_1	756:760	ADTSS	SPOP	0.982	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1113:1117	ADTSS	SPOP	0.995	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	430:434	ADTSS	SPOP	0.8521	More...
Q6ZMY6	WD repeat-containing protein 88	DEG_SPOP_SBC_1	449:453	ADTSS	SPOP	0.5826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons