DegronMD

Uniprot ID: Q7Z417

Source protein: Nuclear fragile X mental retardation-interacting protein 2

Source gene: NUFIP2

Class: DEG_SPOP_SBC_1

Location: 604:608

E3 ligase: SPOP

DEGRON score: 0.9979

ASA_SCORE: 68.26

COIL: 0.707

CONS_SCORE: 0.4918

DSS_SCORE: 0.3649

HELIX: 0.1814

FCONS_SCORE: 1.0884

RIG_SCORE: 0.7026

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S608T	TCGA-AJ-A3EK	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.7116
p.S608T	DO41584	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.7116
p.H597N	DO228948	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1389
p.P595H	DO228974	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.0833
p.Q602K	DO228976	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.2778
p.Q602K	DO229029	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.2778
p.L601M	DO229015	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.25
p.L601P	SIDM00683	Prostate Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.25
p.L601P	ACH-000977	lymph_node	CCLE	ADTSS	DEG_SPOP_SBC_1	0.25
p.L601P	LNCaP-Clone-FGC	prostate	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.25
p.E594D	ACH-000786	Lymphoma	CCLE	ADTSS	DEG_SPOP_SBC_1	0.0556
p.E594D	ACH-000992	Head and Neck Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.0556
p.E594D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.0556
p.E594D	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23759	Paired box protein Pax-7	DEG_SPOP_SBC_1	346:350	ADTSS	SPOP	0.5936	More...
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_SPOP_SBC_1	1386:1390	ADTSS	SPOP	0.8488	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	867:871	ADTSS	SPOP	0.9941	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	227:231	ADTSS	SPOP	0.9912	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	771:775	ADTSS	SPOP	0.8619	More...
Q6UVM3	Potassium channel subfamily T member 2	DEG_SPOP_SBC_1	636:640	ADTSS	SPOP	0.9248	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	604:608	ADTSS	SPOP	0.9979	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_SPOP_SBC_1	1584:1588	ADTSS	SPOP	0.6823	More...
Q96KM6	Zinc finger protein 512B	DEG_SPOP_SBC_1	382:386	ADTSS	SPOP	0.9081	More...
Q99708	DNA endonuclease RBBP8	DEG_SPOP_SBC_1	14:18	ADTSS	SPOP	0.8958	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	2460:2464	ADTSS	SPOP	0.8672	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_SPOP_SBC_1	756:760	ADTSS	SPOP	0.982	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1113:1117	ADTSS	SPOP	0.995	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	430:434	ADTSS	SPOP	0.8521	More...
Q6ZMY6	WD repeat-containing protein 88	DEG_SPOP_SBC_1	449:453	ADTSS	SPOP	0.5826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons