DegronMD - Q96KM6(ZNF512B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G392S	TCGA-BS-A0UF	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1667
p.G392S	DO41488	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1667
p.P727A	TCGA-CG-4460	STAD	TCGA	TRPGLPTLN	DEG_APCC_DBOX_1	725:733	Mutation altering degron motif	0.6392
p.P727A	DO38427	STAD	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	725:733	Mutation altering degron motif	0.6392
p.K741N	TCGA-F5-6814	READ	TCGA	TRPGLPTLN	DEG_APCC_DBOX_1	725:733	Mutation substituting flanking lysine	0.2222
p.K741N	TCGA-IM-A41Y	THCA	TCGA	TRPGLPTLN	DEG_APCC_DBOX_1	725:733	Mutation substituting flanking lysine	0.2222
p.K741N	DO36556	READ	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	725:733	Mutation substituting flanking lysine	0.2222
p.K741N	DO48167	THCA	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	725:733	Mutation substituting flanking lysine	0.2222
p.P395L	DO233267	GACA	ICGC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0833
p.T725N	DO229038	LICA	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	725:733	Mutation altering degron motif	0.5944
p.P395T	DO229037	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0833
p.P717H	DO229045	LICA	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	725:733	Mutation rewiring degron network	0.1111
p.D383E	DO229006	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.5647
p.G373C	DO229213	THCA	ICGC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0833
p.P395S	SIDM00537	Colorectal Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0833
p.P395S	ACH-000982	Colon/Colorectal Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0833
p.P395S	ACH-001345	Colon/Colorectal Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0833
p.P395S	GP5d	large intestine	COSMIC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0833
p.P391T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1944
p.P391T	ACH-000964	Leukemia	CCLE	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1944
p.G387D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.3056

Kaplan plot for ZNF512B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF512B

UniProt ID: Q96KM6

Entrez ID: 57473

Protein name: Zinc finger protein 512B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF512B in