DegronMD

Uniprot ID: Q96KM6

Source protein: Zinc finger protein 512B

Source gene: ZNF512B

Class: DEG_APCC_DBOX_1

Location: 725:733

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 69.2111

COIL: 0.9022

CONS_SCORE: 0.6059

DSS_SCORE: 0.3949

HELIX: 0.0263

FCONS_SCORE: 1.0927

RIG_SCORE: 0.7376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P727A	TCGA-CG-4460	STAD	TCGA	TRPGLPTLN	DEG_APCC_DBOX_1	0.6392
p.P727A	DO38427	STAD	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	0.6392
p.K741N	TCGA-F5-6814	READ	TCGA	TRPGLPTLN	DEG_APCC_DBOX_1	0.2222
p.K741N	TCGA-IM-A41Y	THCA	TCGA	TRPGLPTLN	DEG_APCC_DBOX_1	0.2222
p.K741N	DO36556	READ	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	0.2222
p.K741N	DO48167	THCA	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	0.2222
p.T725N	DO229038	LICA	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	0.5944
p.P717H	DO229045	LICA	ICGC	TRPGLPTLN	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KM6	Zinc finger protein 512B	DEG_APCC_DBOX_1	725:733	TRPGLPTLN	APC,CDC20,FZR1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons