DegronMD

Uniprot ID: P35125

Source protein: Ubiquitin carboxyl-terminal hydrolase 6

Source gene: USP6

Class: DEG_SPOP_SBC_1

Location: 1386:1390

E3 ligase: SPOP

DEGRON score: 0.8488

ASA_SCORE: 82.64

COIL: 0.9252

CONS_SCORE: 0.2223

DSS_SCORE: 0.5472

HELIX: 0.0486

FCONS_SCORE: 0.8268

RIG_SCORE: 0.6729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1394E	TCGA-A5-A0G1	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.2222
p.D1394E	DO42472	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.2222
p.D1398N	TCGA-BF-A5EQ	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1111
p.D1398N	DO219452	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.E1400K	TCGA-ER-A19Q	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	0.0556
p.E1400K	DO228331	BRCA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.0556
p.E1400K	DO218863	SKCA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.0556
p.E1400K	DO47497	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	0.0556
p.D1392N	TCGA-GN-A8LK	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	0.2778
p.D1392N	DO51259	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	0.2778
p.P1378Q	TCGA-L9-A7SV	LUAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1111
p.P1378Q	DO49875	LUAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1111
p.S1395F	DO229030	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.6389
p.T1391M	DO229053	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.75
p.S1389N	DO23466	LINC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23759	Paired box protein Pax-7	DEG_SPOP_SBC_1	346:350	ADTSS	SPOP	0.5936	More...
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_SPOP_SBC_1	1386:1390	ADTSS	SPOP	0.8488	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	867:871	ADTSS	SPOP	0.9941	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	227:231	ADTSS	SPOP	0.9912	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	771:775	ADTSS	SPOP	0.8619	More...
Q6UVM3	Potassium channel subfamily T member 2	DEG_SPOP_SBC_1	636:640	ADTSS	SPOP	0.9248	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	604:608	ADTSS	SPOP	0.9979	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_SPOP_SBC_1	1584:1588	ADTSS	SPOP	0.6823	More...
Q96KM6	Zinc finger protein 512B	DEG_SPOP_SBC_1	382:386	ADTSS	SPOP	0.9081	More...
Q99708	DNA endonuclease RBBP8	DEG_SPOP_SBC_1	14:18	ADTSS	SPOP	0.8958	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	2460:2464	ADTSS	SPOP	0.8672	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_SPOP_SBC_1	756:760	ADTSS	SPOP	0.982	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1113:1117	ADTSS	SPOP	0.995	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	430:434	ADTSS	SPOP	0.8521	More...
Q6ZMY6	WD repeat-containing protein 88	DEG_SPOP_SBC_1	449:453	ADTSS	SPOP	0.5826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons