DegronMD - Q9Y3R5(DOP1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1043S	SIDM02039	Colorectal Carcinoma	GDSC	TSFREACAVPEP	DEG_COP1_1	1034:1045	Mutation altering degron motif	0.6752
p.E1038V	SIDM00541	Colorectal Carcinoma	GDSC	TSFREACAVPEP	DEG_COP1_1	1034:1045	Mutation altering degron motif	0.7693
p.E1038V	HT55	large intestine	COSMIC	TSFREACAVPEP	DEG_COP1_1	1034:1045	Mutation altering degron motif	0.7693
p.R1217S	SIDM00582	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00435	Acute Myeloid Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01020	Plasma Cell Myeloma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00615	Hepatocellular Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00411	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00491	Thyroid Gland Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00781	Colorectal Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00568	Gastric Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00351	Oral Cavity Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00562	Breast Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01045	Endometrial Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00252	Biliary Tract Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00280	Gastric Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01061	Oral Cavity Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00655	Other Solid Cancers	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00271	Gastric Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00469	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00368	Small Cell Lung Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00579	Neuroblastoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00233	T-Lymphoblastic Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00591	Oral Cavity Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00531	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01498	Acute Myeloid Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01471	Chronic Myelogenous Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00780	Colorectal Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01469	Pancreatic Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01435	Hepatocellular Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM00959	Acute Myeloid Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01756	Chronic Myelogenous Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217S	SIDM01618	B-Lymphoblastic Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.P1055S	SIDM00683	Prostate Carcinoma	GDSC	TSFREACAVPEP	DEG_COP1_1	1034:1045	Mutation rewiring degron network	0.0556
p.P1055S	LNCaP-Clone-FGC	prostate	COSMIC	TSFREACAVPEP	DEG_COP1_1	1034:1045	Mutation rewiring degron network	0.0556
p.T1120M	SIDM00330	Neuroblastoma	GDSC	ADTSS	DEG_SPOP_SBC_1	1113:1117	Mutation rewiring degron network	0.25
p.S2066F	SIDM01126	Small Cell Lung Carcinoma	GDSC	FRVLLLRIS	DEG_APCC_DBOX_1	2076:2084	Mutation rewiring degron network	0.0556
p.S2066F	NCI-H64	lung	COSMIC	FRVLLLRIS	DEG_APCC_DBOX_1	2076:2084	Mutation rewiring degron network	0.0556
p.R1217M	SIDM00789	Colorectal Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.R1217M	HCT-15	large intestine	COSMIC	ALTTS	DEG_SPOP_SBC_1	1204:1208	Mutation rewiring degron network	0.0833
p.D1024Y	SIDM00836	Colorectal Carcinoma	GDSC	TSFREACAVPEP	DEG_COP1_1	1034:1045	Mutation rewiring degron network	0.0556
p.D1024Y	SW403	large intestine	COSMIC	TSFREACAVPEP	DEG_COP1_1	1034:1045	Mutation rewiring degron network	0.0556
p.A595V	SIDM00280	Gastric Carcinoma	GDSC	DSGIGLS	DEG_SCF_TRCP1_1	588:594	Mutation rewiring degron network	0.3056
p.A595V	ECC10	stomach	COSMIC	DSGIGLS	DEG_SCF_TRCP1_1	588:594	Mutation rewiring degron network	0.3056
p.W2092L	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	FRVLLLRIS	DEG_APCC_DBOX_1	2076:2084	Mutation rewiring degron network	0.1111
p.W2092L	LCLC-97TM1	lung	COSMIC	FRVLLLRIS	DEG_APCC_DBOX_1	2076:2084	Mutation rewiring degron network	0.1111
p.W2092C	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	FRVLLLRIS	DEG_APCC_DBOX_1	2076:2084	Mutation rewiring degron network	0.1111
p.W2092C	LCLC-97TM1	lung	COSMIC	FRVLLLRIS	DEG_APCC_DBOX_1	2076:2084	Mutation rewiring degron network	0.1111
p.C1118S	SIDM00044	Head and Neck Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	1113:1117	Mutation rewiring degron network	0.3056
p.C1118S	PCI-30	upper aerodigestive tract	COSMIC	ADTSS	DEG_SPOP_SBC_1	1113:1117	Mutation rewiring degron network	0.3056
p.E1123K	SIDM01765	Osteosarcoma	GDSC	ADTSS	DEG_SPOP_SBC_1	1113:1117	Mutation rewiring degron network	0.1667
p.S1117C	Sarc9371	bone	COSMIC	ADTSS	DEG_SPOP_SBC_1	1113:1117	Mutation altering degron motif	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOP1B

UniProt ID: Q9Y3R5

Entrez ID: 9980

Protein name: Protein dopey-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOP1B in