DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGIGLS
Uniprot ID:
Q9Y3R5
Source protein:
Protein dopey-2
Source gene:
DOP1B
Class:
DEG_SCF_TRCP1_1
Location:
588:594
E3 ligase:
BTRC
DEGRON score:
0.9989
ASA_SCORE:
64.1143
COIL:
0.8383
CONS_SCORE:
0.2757
DSS_SCORE:
0.5491
HELIX:
0.0736
FCONS_SCORE:
1.0726
RIG_SCORE:
0.6133
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A595V
SIDM00280
Gastric Carcinoma
GDSC
DSGIGLS
DEG_SCF_TRCP1_1
0.3056
p.A595V
ECC10
stomach
COSMIC
DSGIGLS
DEG_SCF_TRCP1_1
0.3056
Drug responses associated with DOP1B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGIGLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y3R5
Protein dopey-2
DEG_SCF_TRCP1_1
588:594
DSGIGLS
BTRC
0.9989
More...