DegronMD

Uniprot ID: Q9Y3R5

Source protein: Protein dopey-2

Source gene: DOP1B

Class: DEG_APCC_DBOX_1

Location: 2076:2084

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6774

ASA_SCORE: 41.5889

COIL: 0.3256

CONS_SCORE: 0.6763

DSS_SCORE: 0.0013

HELIX: 0.662

FCONS_SCORE: 1.2936

RIG_SCORE: 0.9789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2066F	SIDM01126	Small Cell Lung Carcinoma	GDSC	FRVLLLRIS	DEG_APCC_DBOX_1	0.0556
p.S2066F	NCI-H64	lung	COSMIC	FRVLLLRIS	DEG_APCC_DBOX_1	0.0556
p.W2092L	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	FRVLLLRIS	DEG_APCC_DBOX_1	0.1111
p.W2092L	LCLC-97TM1	lung	COSMIC	FRVLLLRIS	DEG_APCC_DBOX_1	0.1111
p.W2092C	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	FRVLLLRIS	DEG_APCC_DBOX_1	0.1111
p.W2092C	LCLC-97TM1	lung	COSMIC	FRVLLLRIS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3R5	Protein dopey-2	DEG_APCC_DBOX_1	2076:2084	FRVLLLRIS	APC,CDC20,FZR1	0.6774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons