DegronMD

Uniprot ID: Q9Y3R5

Source protein: Protein dopey-2

Source gene: DOP1B

Class: DEG_COP1_1

Location: 1034:1045

E3 ligase: COP1

DEGRON score: 0.6852

ASA_SCORE: 84.8917

COIL: 0.7423

CONS_SCORE: 0.2448

DSS_SCORE: 0.4999

HELIX: 0.198

FCONS_SCORE: 0.9686

RIG_SCORE: 0.7179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1043S	SIDM02039	Colorectal Carcinoma	GDSC	TSFREACAVPEP	DEG_COP1_1	0.6752
p.E1038V	SIDM00541	Colorectal Carcinoma	GDSC	TSFREACAVPEP	DEG_COP1_1	0.7693
p.E1038V	HT55	large_intestine	COSMIC	TSFREACAVPEP	DEG_COP1_1	0.7693
p.P1055S	SIDM00683	Prostate Carcinoma	GDSC	TSFREACAVPEP	DEG_COP1_1	0.0556
p.P1055S	LNCaP-Clone-FGC	prostate	COSMIC	TSFREACAVPEP	DEG_COP1_1	0.0556
p.D1024Y	SIDM00836	Colorectal Carcinoma	GDSC	TSFREACAVPEP	DEG_COP1_1	0.0556
p.D1024Y	SW403	large_intestine	COSMIC	TSFREACAVPEP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3R5	Protein dopey-2	DEG_COP1_1	1034:1045	TSFREACAVPEP	COP1	0.6852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons