DegronMD - Q7Z417(NUFIP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S383C	TCGA-05-5715	LUAD	TCGA	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.3056
p.S383C	TCGA-05-5715	LUAD	TCGA	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2778
p.S383C	DO25464	LUAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.3056
p.S383C	DO25464	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2778
p.V353L	TCGA-50-5049	LUAD	TCGA	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.0833
p.V353L	DO23705	LUAD	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.0833
p.S608T	TCGA-AJ-A3EK	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation altering degron motif	0.7116
p.S608T	DO41584	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation altering degron motif	0.7116
p.K368T	TCGA-AJ-A3EL	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation substituting flanking lysine	0.1944
p.K368T	TCGA-DK-A6AW	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation substituting flanking lysine	0.1944
p.K368T	DO48566	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation substituting flanking lysine	0.1944
p.K368T	DO41542	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation substituting flanking lysine	0.1944
p.S373F	TCGA-CV-A45U	HNSC	TCGA	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1389
p.S373F	TCGA-CV-A45U	HNSC	TCGA	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2222
p.S373F	DO52057	HNSC	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1389
p.S373F	DO52057	HNSC	ICGC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2222
p.L443V	TCGA-D7-5578	STAD	TCGA	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation altering degron motif	0.5654
p.L443V	DO38475	STAD	ICGC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation altering degron motif	0.5654
p.S386Y	TCGA-E2-A10C	BRCA	TCGA	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation altering degron motif	0.8231
p.S386Y	DO1334	BRCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation altering degron motif	0.8231
p.S360N	TCGA-EB-A3Y6	SKCM	TCGA	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2778
p.S360N	DO38081	SKCM	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2778
p.P354L	TCGA-EE-A3AA	SKCM	TCGA	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1111
p.P354L	DO222632	MELA	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1111
p.P354L	DO37571	SKCM	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1111
p.S374Y	TCGA-EO-A3B0	UCEC	TCGA	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation blocking phosphorylation signal	0.5556
p.S374Y	TCGA-EO-A3B0	UCEC	TCGA	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation blocking phosphorylation signal	0.5
p.S374Y	TCGA-EO-A3B0	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation blocking phosphorylation signal	0.6944
p.S374Y	DO219773	UCEC	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation blocking phosphorylation signal	0.5556
p.S374Y	DO219773	UCEC	ICGC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation blocking phosphorylation signal	0.5
p.S374Y	DO219773	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation blocking phosphorylation signal	0.6944
p.N372T	TCGA-EY-A1GD	UCEC	TCGA	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.N372T	TCGA-EY-A1GD	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.1944
p.N372T	DO42129	UCEC	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.N372T	DO42129	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.1944
p.M457I	TCGA-ZF-AA4W	BLCA	TCGA	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.0833
p.M457I	DO219089	BLCA	ICGC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.0833
p.Q433H	DO10844	ESAD	ICGC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.0556
p.H597N	DO228948	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.1389
p.P595H	DO228974	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.0833
p.Q602K	DO228976	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.2778
p.Q602K	DO229029	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.2778
p.L601M	DO229015	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.25
p.S360R	DO229026	LICA	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2778
p.T450R	DO52365	LUSC	ICGC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.2778
p.T450R	SIDM00569	Osteosarcoma	GDSC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.2778
p.T450R	SIDM00235	Kidney Carcinoma	GDSC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.2778
p.T450R	SIDM00299	Other Sarcomas	GDSC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.2778
p.T450R	SIDM00500	Colorectal Carcinoma	GDSC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.2778
p.Y358D	DO222875	MELA	ICGC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.T450S	DO46443	OV	ICGC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation rewiring degron network	0.2778
p.L601P	SIDM00683	Prostate Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.25
p.L601P	ACH-000977	lymph node	CCLE	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.25
p.L601P	LNCaP-Clone-FGC	prostate	COSMIC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.25
p.S394T	SIDM00773	Non-Cancerous	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.1944
p.S394T	SIDM00032	Bladder Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.1944
p.S394T	SIDM00774	Breast Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.1944
p.I370V	SIDM00845	Burkitt's Lymphoma	GDSC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.I370V	SIDM00845	Burkitt's Lymphoma	GDSC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.1389
p.I370V	SIDM00461	Acute Myeloid Leukemia	GDSC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.I370V	SIDM00461	Acute Myeloid Leukemia	GDSC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.1389
p.I370V	SIDM01519	Head and Neck Carcinoma	GDSC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.I370V	SIDM01519	Head and Neck Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.1389
p.I370V	ACH-000786	Lymphoma	CCLE	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.I370V	ACH-000786	Lymphoma	CCLE	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.1389
p.V353A	SIDM00480	Ovarian Carcinoma	GDSC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.0833
p.V353A	ACH-000704	Ovarian Cancer	CCLE	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.0833
p.V353A	OAW-42	ovary	COSMIC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.0833
p.T392A	SIDM00255	Neuroblastoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM00197	Ewing's Sarcoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM00402	Bladder Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM00752	Non-Cancerous	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM00814	Other Solid Cancers	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM01323	Oral Cavity Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM01640	Acute Myeloid Leukemia	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM01725	Non-Cancerous	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.T392A	SIDM01665	Colorectal Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation rewiring degron network	0.25
p.G388R	SIDM00429	B-Lymphoblastic Leukemia	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation altering degron motif	0.7568
p.G388R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation altering degron motif	0.7568
p.G388R	ACH-000918	Leukemia	CCLE	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation altering degron motif	0.7568
p.G388R	ACH-000938	Leukemia	CCLE	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation altering degron motif	0.7568
p.G388R	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation altering degron motif	0.7568
p.G388R	NALM-6	haematopoietic and lymphoid tissue	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	384:389	Mutation altering degron motif	0.7568
p.P445L	SIDM00217	Colorectal Carcinoma	GDSC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation altering degron motif	0.7582
p.P445L	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation altering degron motif	0.7582
p.P445L	SNU-1040	large intestine	COSMIC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation altering degron motif	0.7582
p.P445S	SIDM00217	Colorectal Carcinoma	GDSC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation altering degron motif	0.6752
p.P445S	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation altering degron motif	0.6752
p.P445S	SNU-1040	large intestine	COSMIC	LTPISS	DEG_SCF_FBW7_1	443:448	Mutation altering degron motif	0.6752
p.N372S	SIDM01397	Melanoma	GDSC	VKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.N372S	SIDM01397	Melanoma	GDSC	PTSSS	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.1944
p.E594D	ACH-000786	Lymphoma	CCLE	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.0556
p.E594D	ACH-000992	Head and Neck Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.0556
p.E594D	Daudi	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.0556
p.E594D	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUFIP2

UniProt ID: Q7Z417

Entrez ID: 57532

Protein name: Nuclear fragile X mental retardation-interacting protein 2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUFIP2 in