DegronMD

Uniprot ID: Q7Z417

Source protein: Nuclear fragile X mental retardation-interacting protein 2

Source gene: NUFIP2

Class: DEG_APCC_KENBOX_2

Location: 362:366

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9985

ASA_SCORE: 97.22

COIL: 0.7614

CONS_SCORE: 0.9502

DSS_SCORE: 0.392

HELIX: 0.2022

FCONS_SCORE: 1.422

RIG_SCORE: 0.7624

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S374Y	TCGA-EO-A3B0	UCEC	TCGA	VKENL	DEG_APCC_KENBOX_2	0.5556
p.S374Y	DO219773	UCEC	ICGC	VKENL	DEG_APCC_KENBOX_2	0.5556
p.S360N	TCGA-EB-A3Y6	SKCM	TCGA	VKENL	DEG_APCC_KENBOX_2	0.2778
p.S360N	DO38081	SKCM	ICGC	VKENL	DEG_APCC_KENBOX_2	0.2778
p.S360R	DO229026	LICA	ICGC	VKENL	DEG_APCC_KENBOX_2	0.2778
p.Y358D	DO222875	MELA	ICGC	VKENL	DEG_APCC_KENBOX_2	0.2222
p.I370V	SIDM00845	Burkitt's Lymphoma	GDSC	VKENL	DEG_APCC_KENBOX_2	0.2222
p.I370V	SIDM00461	Acute Myeloid Leukemia	GDSC	VKENL	DEG_APCC_KENBOX_2	0.2222
p.I370V	SIDM01519	Head and Neck Carcinoma	GDSC	VKENL	DEG_APCC_KENBOX_2	0.2222
p.I370V	ACH-000786	Lymphoma	CCLE	VKENL	DEG_APCC_KENBOX_2	0.2222
p.N372T	TCGA-EY-A1GD	UCEC	TCGA	VKENL	DEG_APCC_KENBOX_2	0.1667
p.N372T	DO42129	UCEC	ICGC	VKENL	DEG_APCC_KENBOX_2	0.1667
p.N372S	SIDM01397	Melanoma	GDSC	VKENL	DEG_APCC_KENBOX_2	0.1667
p.S373F	TCGA-CV-A45U	HNSC	TCGA	VKENL	DEG_APCC_KENBOX_2	0.1389
p.S373F	DO52057	HNSC	ICGC	VKENL	DEG_APCC_KENBOX_2	0.1389
p.P354L	TCGA-EE-A3AA	SKCM	TCGA	VKENL	DEG_APCC_KENBOX_2	0.1111
p.P354L	DO222632	MELA	ICGC	VKENL	DEG_APCC_KENBOX_2	0.1111
p.P354L	DO37571	SKCM	ICGC	VKENL	DEG_APCC_KENBOX_2	0.1111
p.V353L	TCGA-50-5049	LUAD	TCGA	VKENL	DEG_APCC_KENBOX_2	0.0833
p.V353L	DO23705	LUAD	ICGC	VKENL	DEG_APCC_KENBOX_2	0.0833
p.V353A	SIDM00480	Ovarian Carcinoma	GDSC	VKENL	DEG_APCC_KENBOX_2	0.0833
p.V353A	ACH-000704	Ovarian Cancer	CCLE	VKENL	DEG_APCC_KENBOX_2	0.0833
p.V353A	OAW-42	ovary	COSMIC	VKENL	DEG_APCC_KENBOX_2	0.0833

Showing 1 to 23 of 23 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_APCC_KENBOX_2	362:366	VKENL	APC,CDC20,FZR1	0.9985	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons