DegronMD

Uniprot ID: Q7Z417

Source protein: Nuclear fragile X mental retardation-interacting protein 2

Source gene: NUFIP2

Class: DEG_SCF_FBW7_1

Location: 443:448

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 74.8167

COIL: 0.9475

CONS_SCORE: 0.5046

DSS_SCORE: 0.3881

HELIX: 0.0158

FCONS_SCORE: 1.1434

RIG_SCORE: 0.7324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L443V	TCGA-D7-5578	STAD	TCGA	LTPISS	DEG_SCF_FBW7_1	0.5654
p.L443V	DO38475	STAD	ICGC	LTPISS	DEG_SCF_FBW7_1	0.5654
p.M457I	TCGA-ZF-AA4W	BLCA	TCGA	LTPISS	DEG_SCF_FBW7_1	0.0833
p.M457I	DO219089	BLCA	ICGC	LTPISS	DEG_SCF_FBW7_1	0.0833
p.Q433H	DO10844	ESAD	ICGC	LTPISS	DEG_SCF_FBW7_1	0.0556
p.T450R	DO52365	LUSC	ICGC	LTPISS	DEG_SCF_FBW7_1	0.2778
p.T450R	SIDM00569	Osteosarcoma	GDSC	LTPISS	DEG_SCF_FBW7_1	0.2778
p.T450R	SIDM00235	Kidney Carcinoma	GDSC	LTPISS	DEG_SCF_FBW7_1	0.2778
p.T450R	SIDM00299	Other Sarcomas	GDSC	LTPISS	DEG_SCF_FBW7_1	0.2778
p.T450R	SIDM00500	Colorectal Carcinoma	GDSC	LTPISS	DEG_SCF_FBW7_1	0.2778
p.T450S	DO46443	OV	ICGC	LTPISS	DEG_SCF_FBW7_1	0.2778
p.P445L	SIDM00217	Colorectal Carcinoma	GDSC	LTPISS	DEG_SCF_FBW7_1	0.7582
p.P445L	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPISS	DEG_SCF_FBW7_1	0.7582
p.P445L	SNU-1040	large_intestine	COSMIC	LTPISS	DEG_SCF_FBW7_1	0.7582
p.P445S	SIDM00217	Colorectal Carcinoma	GDSC	LTPISS	DEG_SCF_FBW7_1	0.6752
p.P445S	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPISS	DEG_SCF_FBW7_1	0.6752
p.P445S	SNU-1040	large_intestine	COSMIC	LTPISS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SCF_FBW7_1	443:448	LTPISS	FBXW7	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons