DegronMD

Uniprot ID: Q7Z417

Source protein: Nuclear fragile X mental retardation-interacting protein 2

Source gene: NUFIP2

Class: DEG_Kelch_Keap1_1

Location: 384:389

E3 ligase: KEAP1

DEGRON score: 0.9885

ASA_SCORE: 76.8667

COIL: 0.903

CONS_SCORE: 0.5147

DSS_SCORE: 0.6573

HELIX: 0.0493

FCONS_SCORE: 1.3003

RIG_SCORE: 0.4884

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S383C	TCGA-05-5715	LUAD	TCGA	SSSTGE	DEG_Kelch_Keap1_1	0.3056
p.S383C	DO25464	LUAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.3056
p.S386Y	TCGA-E2-A10C	BRCA	TCGA	SSSTGE	DEG_Kelch_Keap1_1	0.8231
p.S386Y	DO1334	BRCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.8231
p.S374Y	TCGA-EO-A3B0	UCEC	TCGA	SSSTGE	DEG_Kelch_Keap1_1	0.5
p.S374Y	DO219773	UCEC	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.5
p.S394T	SIDM00773	Non-Cancerous	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.1944
p.S394T	SIDM00032	Bladder Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.1944
p.S394T	SIDM00774	Breast Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.1944
p.T392A	SIDM00255	Neuroblastoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM00197	Ewing's Sarcoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM00402	Bladder Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM00752	Non-Cancerous	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM00814	Other Solid Cancers	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM01323	Oral Cavity Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM01640	Acute Myeloid Leukemia	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM01725	Non-Cancerous	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T392A	SIDM01665	Colorectal Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.G388R	SIDM00429	B-Lymphoblastic Leukemia	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.7568
p.G388R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.7568
p.G388R	ACH-000918	Leukemia	CCLE	SSSTGE	DEG_Kelch_Keap1_1	0.7568
p.G388R	ACH-000938	Leukemia	CCLE	SSSTGE	DEG_Kelch_Keap1_1	0.7568
p.G388R	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.7568
p.G388R	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_Kelch_Keap1_1	384:389	SSSTGE	KEAP1	0.9885	More...
Q96CP6	Protein Aster-A	DEG_Kelch_Keap1_1	350:355	SSSTGE	KEAP1	0.9989	More...
Q2TAC6	Kinesin-like protein KIF19	DEG_Kelch_Keap1_1	847:852	SSSTGE	KEAP1	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSSTGE

Degron related mutations and impact score

Drug responses associated with NUFIP2 mutations

All proteins holding degron of SSSTGE