DegronMD

Uniprot ID: Q2TAC6

Source protein: Kinesin-like protein KIF19

Source gene: KIF19

Class: DEG_Kelch_Keap1_1

Location: 847:852

E3 ligase: KEAP1

DEGRON score: 0.9836

ASA_SCORE: 74.5833

COIL: 0.845

CONS_SCORE: 0.463

DSS_SCORE: 0.734

HELIX: 0.0975

FCONS_SCORE: 1.2268

RIG_SCORE: 0.5405

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G862V	TCGA-55-A4DG	LUAD	TCGA	SSSTGE	DEG_Kelch_Keap1_1	0.0556
p.G862V	DO26337	LUAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.0556
p.A853D	TCGA-CC-5262	LIHC	TCGA	SSSTGE	DEG_Kelch_Keap1_1	0.3056
p.A853D	DO22953	LIHC	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.3056
p.A853V	TCGA-DK-A6AW	BLCA	TCGA	SSSTGE	DEG_Kelch_Keap1_1	0.3056
p.A853V	DO48566	BLCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.3056
p.E852Q	TCGA-XF-AAN5	BLCA	TCGA	SSSTGE	DEG_Kelch_Keap1_1	0.6744
p.E852Q	DO51945	BLCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.6744
p.E852K	DO234201	ESAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.7022
p.T850K	DO234379	ESAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.7306
p.A853S	DO228985	LICA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.3056
p.H860L	DO231393	THCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.1111
p.R856Q	SIDM00304	Ovarian Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.2222
p.G859R	SIDM00652	Small Cell Lung Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.1389
p.G859R	ACH-000780	Lung Cancer	CCLE	SSSTGE	DEG_Kelch_Keap1_1	0.1389
p.G859R	NCI-H1105	lung	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.1389
p.R856W	SIDM00566	Oral Cavity Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.2222
p.R856W	SIDM00161	Biliary Tract Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.2222
p.R856W	SIDM01574	Plasma Cell Myeloma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.2222
p.R856W	OSC-19	upper_aerodigestive_tract	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_Kelch_Keap1_1	384:389	SSSTGE	KEAP1	0.9885	More...
Q96CP6	Protein Aster-A	DEG_Kelch_Keap1_1	350:355	SSSTGE	KEAP1	0.9989	More...
Q2TAC6	Kinesin-like protein KIF19	DEG_Kelch_Keap1_1	847:852	SSSTGE	KEAP1	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons