p.S284G | TCGA-18-5595 | LUSC | TCGA | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.25 |
p.S284I | TCGA-18-5595 | LUSC | TCGA | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.25 |
p.S284I | TCGA-CI-6624 | READ | TCGA | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.25 |
p.L538V | TCGA-2H-A9GF | ESCA | TCGA | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1389 |
p.R562L | TCGA-56-8083 | LUSC | TCGA | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.0833 |
p.R555W | TCGA-A5-A0G2 | UCEC | TCGA | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.2778 |
p.P278S | TCGA-AD-6889 | COAD | TCGA | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation altering degron motif | 0.6752 |
p.S351P | TCGA-AX-A1CE | UCEC | TCGA | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation altering degron motif | 0.5641 |
p.A287T | TCGA-AX-A2HD | UCEC | TCGA | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1667 |
p.A287T | SIDM01007 | T-Lymphoblastic Leukemia | GDSC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1667 |
p.A287T | KARPAS-45 | haematopoietic and lymphoid tissue | COSMIC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1667 |
p.D288H | TCGA-AX-A2IO | UCEC | TCGA | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1389 |
p.R546L | TCGA-DJ-A2QB | THCA | TCGA | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation altering degron motif | 0.8428 |
p.S537F | TCGA-ER-A19D | SKCM | TCGA | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1111 |
p.P313R | TCGA-GL-A4EM | KIRP | TCGA | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation altering degron motif | 0.7512 |
p.R553Q | TCGA-NC-A5HJ | LUSC | TCGA | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation altering degron motif | 0.6218 |
p.E288Q | DO856 | BLCA | ICGC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1389 |
p.T551M | DO49806 | BLCA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation altering degron motif | 0.7423 |
p.T551M | DO233944 | GACA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation altering degron motif | 0.7423 |
p.T551M | GP5d | large intestine | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation altering degron motif | 0.7423 |
p.R536H | DO219072 | BLCA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.0833 |
p.Y317S | DO2156 | BRCA | ICGC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.3056 |
p.S319F | DO219759 | CESC | ICGC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.25 |
p.G542W | DO10582 | COAD | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.25 |
p.G542W | DO229031 | LICA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.25 |
p.G542W | DO229008 | LICA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.25 |
p.S350N | DO10140 | COAD | ICGC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation altering degron motif | 0.5958 |
p.P365S | DO8463 | COAD | ICGC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.0556 |
p.R535W | DO234285 | ESAD | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation blocking ubiquitination signal | 0.5 |
p.A347V | DO233041 | GACA | ICGC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.25 |
p.A347V | DO229240 | THCA | ICGC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.25 |
p.T364M | DO233245 | GACA | ICGC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.0833 |
p.Q539H | DO233272 | GACA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1667 |
p.R280H | DO219869 | LGG | ICGC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation altering degron motif | 0.8244 |
p.R280H | DO228138 | PBCA | ICGC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation altering degron motif | 0.8244 |
p.I554N | DO228934 | LICA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.3056 |
p.I554N | COLO-792 | skin | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.3056 |
p.D314Y | DO229028 | LICA | ICGC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation altering degron motif | 0.7325 |
p.D558Y | DO229025 | LICA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1944 |
p.S547F | DO220860 | MELA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation altering degron motif | 0.7982 |
p.G269E | DO222542 | MELA | ICGC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1389 |
p.S358L | DO222572 | MELA | ICGC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.25 |
p.S358L | C-33-A | cervix | COSMIC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.25 |
p.R273H | DO27927 | ORCA | ICGC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.25 |
p.Y561C | DO232224 | PBCA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1111 |
p.Y559C | DO232532 | PBCA | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1667 |
p.R536C | DO51407 | PRAD | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.0833 |
p.R536C | DO41871 | UCEC | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.0833 |
p.G542R | DO47667 | SKCM | ICGC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.25 |
p.G542R | SIDM00998 | Glioblastoma | GDSC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.25 |
p.G542R | 8-MG-BA | central nervous system | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.25 |
p.T342I | DO51270 | SKCM | ICGC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.1111 |
p.R273C | DO47985 | STAD | ICGC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.25 |
p.F268S | DO48174 | UCEC | ICGC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1111 |
p.G305D | DO42673 | UCEC | ICGC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.1667 |
p.D286N | SIDM01300 | Colorectal Carcinoma | GDSC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1944 |
p.D286N | SIDM00665 | Gastric Carcinoma | GDSC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1944 |
p.D286N | Hs746T | stomach | COSMIC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1944 |
p.A361G | SIDM00741 | Small Cell Lung Carcinoma | GDSC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.1667 |
p.S560N | SIDM00908 | Non-Cancerous | GDSC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation blocking phosphorylation signal | 0.5833 |
p.S560N | SIDM00909 | Melanoma | GDSC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation blocking phosphorylation signal | 0.5833 |
p.G354V | SIDM00320 | Non-Small Cell Lung Carcinoma | GDSC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation altering degron motif | 0.7532 |
p.G354V | VMRC-LCD | lung | COSMIC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation altering degron motif | 0.7532 |
p.S271L | SIDM00889 | Cervical Carcinoma | GDSC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation blocking phosphorylation signal | 0.6389 |
p.S271L | C-33-A | cervix | COSMIC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation blocking phosphorylation signal | 0.6389 |
p.D358E | SIDM00333 | Endometrial Carcinoma | GDSC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.25 |
p.D358E | MFE-319 | endometrium | COSMIC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.25 |
p.P313T | SIDM00596 | Endometrial Carcinoma | GDSC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation altering degron motif | 0.7031 |
p.P313T | HEC-1 | endometrium | COSMIC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation altering degron motif | 0.7031 |
p.S319R | SIDM00247 | Gastric Carcinoma | GDSC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.25 |
p.S319R | MKN45 | stomach | COSMIC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.25 |
p.G541S | SIDM00006 | Other Solid Cancers | GDSC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.2222 |
p.G541S | LNCaP-Clone-FGC | prostate | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.2222 |
p.G541S | MCC26 | skin | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.2222 |
p.G541D | SIDM00006 | Other Solid Cancers | GDSC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.2222 |
p.G541D | MCC26 | skin | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.2222 |
p.R272C | SIDM01131 | Small Cell Lung Carcinoma | GDSC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.2222 |
p.G535R | ACH-000137 | Brain Cancer | CCLE | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation blocking ubiquitination signal | 0.5 |
p.G535R | 8-MG-BA | central nervous system | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation blocking ubiquitination signal | 0.5 |
p.S312R | ACH-000356 | Gastric Cancer | CCLE | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation altering degron motif | 0.7427 |
p.S312R | MKN45 | stomach | COSMIC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation altering degron motif | 0.7427 |
p.S553N | ACH-000644 | Skin Cancer | CCLE | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation altering degron motif | 0.7069 |
p.S553N | ACH-002380 | Non-Cancerous | CCLE | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation altering degron motif | 0.7069 |
p.P306T | ACH-000941 | Endometrial/Uterine Cancer | CCLE | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.1944 |
p.P306T | ACH-000954 | Endometrial/Uterine Cancer | CCLE | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.1944 |
p.P306T | ACH-001517 | Endometrial/Uterine Cancer | CCLE | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.1944 |
p.P306T | HEC-1 | endometrium | COSMIC | VTPVAE | DEG_SCF_FBW7_2 | 311:316 | Mutation rewiring degron network | 0.1944 |
p.D287N | ACH-000969 | Colon/Colorectal Cancer | CCLE | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1667 |
p.D287N | KM12 | large intestine | COSMIC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.1667 |
p.P561S | ACH-000987 | Skin Cancer | CCLE | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1111 |
p.P561S | Mewo | skin | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1111 |
p.D351E | ACH-000988 | Endometrial/Uterine Cancer | CCLE | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation altering degron motif | 0.6758 |
p.D351E | MFE-319 | endometrium | COSMIC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation altering degron motif | 0.6758 |
p.G558W | ACH-000994 | Endometrial/Uterine Cancer | CCLE | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1944 |
p.G361S | ACH-001228 | | CCLE | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.1667 |
p.G347V | ACH-001233 | Lung Cancer | CCLE | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.25 |
p.G347V | VMRC-LCD | lung | COSMIC | SSSTGE | DEG_Kelch_Keap1_1 | 350:355 | Mutation rewiring degron network | 0.25 |
p.R275Q | ACH-001414 | Bladder Cancer | CCLE | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation rewiring degron network | 0.3056 |
p.A280T | ACH-002256 | Leukemia | CCLE | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation altering degron motif | 0.7139 |
p.A280T | KARPAS-45 | haematopoietic and lymphoid tissue | COSMIC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation altering degron motif | 0.7139 |
p.D537A | ACH-002659 | Colon/Colorectal Cancer | CCLE | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.1111 |
p.I554V | COLO-792 | skin | COSMIC | ARGLLSGLR | DEG_APCC_DBOX_1 | 545:553 | Mutation rewiring degron network | 0.3056 |
p.D279N | Hs746T | stomach | COSMIC | VTPNLS | DEG_SCF_FBW7_1 | 276:281 | Mutation altering degron motif | 0.6932 |