DegronMD

Uniprot ID: Q96CP6

Source protein: Protein Aster-A

Source gene: GRAMD1A

Class: DEG_SCF_FBW7_2

Location: 311:316

E3 ligase: FBXW7

DEGRON score: 0.8675

ASA_SCORE: 80.5333

COIL: 0.9085

CONS_SCORE: 0.2621

DSS_SCORE: 0.8877

HELIX: 0.0245

FCONS_SCORE: 0.8847

RIG_SCORE: 0.5874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P313R	TCGA-GL-A4EM	KIRP	TCGA	VTPVAE	DEG_SCF_FBW7_2	0.7512
p.Y317S	DO2156	BRCA	ICGC	VTPVAE	DEG_SCF_FBW7_2	0.3056
p.S319F	DO219759	CESC	ICGC	VTPVAE	DEG_SCF_FBW7_2	0.25
p.D314Y	DO229028	LICA	ICGC	VTPVAE	DEG_SCF_FBW7_2	0.7325
p.G305D	DO42673	UCEC	ICGC	VTPVAE	DEG_SCF_FBW7_2	0.1667
p.P313T	SIDM00596	Endometrial Carcinoma	GDSC	VTPVAE	DEG_SCF_FBW7_2	0.7031
p.P313T	HEC-1	endometrium	COSMIC	VTPVAE	DEG_SCF_FBW7_2	0.7031
p.S319R	SIDM00247	Gastric Carcinoma	GDSC	VTPVAE	DEG_SCF_FBW7_2	0.25
p.S319R	MKN45	stomach	COSMIC	VTPVAE	DEG_SCF_FBW7_2	0.25
p.S312R	ACH-000356	Gastric Cancer	CCLE	VTPVAE	DEG_SCF_FBW7_2	0.7427
p.S312R	MKN45	stomach	COSMIC	VTPVAE	DEG_SCF_FBW7_2	0.7427
p.P306T	ACH-000941	Endometrial/Uterine Cancer	CCLE	VTPVAE	DEG_SCF_FBW7_2	0.1944
p.P306T	ACH-000954	Endometrial/Uterine Cancer	CCLE	VTPVAE	DEG_SCF_FBW7_2	0.1944
p.P306T	ACH-001517	Endometrial/Uterine Cancer	CCLE	VTPVAE	DEG_SCF_FBW7_2	0.1944
p.P306T	HEC-1	endometrium	COSMIC	VTPVAE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CP6	Protein Aster-A	DEG_SCF_FBW7_2	311:316	VTPVAE	FBXW7	0.8675	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons