DegronMD

Uniprot ID: Q96CP6

Source protein: Protein Aster-A

Source gene: GRAMD1A

Class: DEG_Kelch_Keap1_1

Location: 350:355

E3 ligase: KEAP1

DEGRON score: 0.9989

ASA_SCORE: 80.6

COIL: 0.8157

CONS_SCORE: 0.3305

DSS_SCORE: 0.5606

HELIX: 0.1503

FCONS_SCORE: 1.2054

RIG_SCORE: 0.6222

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S351P	TCGA-AX-A1CE	UCEC	TCGA	SSSTGE	DEG_Kelch_Keap1_1	0.5641
p.S350N	DO10140	COAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.5958
p.P365S	DO8463	COAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.0556
p.A347V	DO233041	GACA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.A347V	DO229240	THCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T364M	DO233245	GACA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.0833
p.S358L	DO222572	MELA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.S358L	C-33-A	cervix	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.T342I	DO51270	SKCM	ICGC	SSSTGE	DEG_Kelch_Keap1_1	0.1111
p.A361G	SIDM00741	Small Cell Lung Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.1667
p.G354V	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.7532
p.G354V	VMRC-LCD	lung	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.7532
p.D358E	SIDM00333	Endometrial Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.D358E	MFE-319	endometrium	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.D351E	ACH-000988	Endometrial/Uterine Cancer	CCLE	SSSTGE	DEG_Kelch_Keap1_1	0.6758
p.D351E	MFE-319	endometrium	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.6758
p.G361S	ACH-001228		CCLE	SSSTGE	DEG_Kelch_Keap1_1	0.1667
p.G347V	ACH-001233	Lung Cancer	CCLE	SSSTGE	DEG_Kelch_Keap1_1	0.25
p.G347V	VMRC-LCD	lung	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_Kelch_Keap1_1	384:389	SSSTGE	KEAP1	0.9885	More...
Q96CP6	Protein Aster-A	DEG_Kelch_Keap1_1	350:355	SSSTGE	KEAP1	0.9989	More...
Q2TAC6	Kinesin-like protein KIF19	DEG_Kelch_Keap1_1	847:852	SSSTGE	KEAP1	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons