DegronMD - Q2TAC6(KIF19)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E817K	TCGA-44-5644	LUAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.1944
p.E817K	DO25153	LUAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.1944
p.S811C	TCGA-46-6026	LUSC	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.643
p.S811C	DO26740	LUSC	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.643
p.G862V	TCGA-55-A4DG	LUAD	TCGA	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.0556
p.G862V	DO26337	LUAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.0556
p.L793V	TCGA-63-A5MH	LUSC	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.1111
p.L793V	DO219146	LUSC	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.1111
p.L812M	TCGA-91-6829	LUAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.5999
p.L812M	DO23564	LUAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.5999
p.T715S	TCGA-AA-3864	COAD	TCGA	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1944
p.T715S	DO8490	COAD	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1944
p.P669L	TCGA-BF-AAOU	SKCM	TCGA	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation altering degron motif	0.7582
p.P669L	DO219460	SKCM	ICGC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation altering degron motif	0.7582
p.P729L	TCGA-CA-6718	COAD	TCGA	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1944
p.P729L	DO7801	COAD	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1944
p.A853D	TCGA-CC-5262	LIHC	TCGA	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.3056
p.A853D	DO22953	LIHC	ICGC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.3056
p.T795P	TCGA-CG-5727	STAD	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.1667
p.T795P	DO38511	STAD	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.1667
p.A853V	TCGA-DK-A6AW	BLCA	TCGA	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.3056
p.A853V	DO48566	BLCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.3056
p.G716V	TCGA-ED-A459	LIHC	TCGA	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.2222
p.G716V	DO44974	LIHC	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.2222
p.A821T	TCGA-EK-A3GK	CESC	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.0833
p.A821T	DO49964	CESC	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.0833
p.S723F	TCGA-EO-A3B0	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7982
p.S723F	DO222532	MELA	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7982
p.S723F	DO219773	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7982
p.L680M	TCGA-ER-A1A1	SKCM	TCGA	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.1111
p.L680M	DO37413	SKCM	ICGC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.1111
p.P730L	TCGA-EY-A1GO	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1667
p.P730L	DO41392	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1667
p.A717T	TCGA-FR-A726	SKCM	TCGA	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.25
p.A717T	DO48665	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.25
p.A670T	TCGA-KN-8427	KICH	TCGA	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation altering degron motif	0.6028
p.A670T	DO220479	KICH	ICGC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation altering degron motif	0.6028
p.S663C	TCGA-MT-A67F	HNSC	TCGA	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.2778
p.S663C	DO49070	HNSC	ICGC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.2778
p.S722N	TCGA-VQ-A91D	STAD	TCGA	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7069
p.S722N	DO51783	STAD	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7069
p.S816N	TCGA-WE-AAA3	SKCM	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.2222
p.S816N	DO51295	SKCM	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.2222
p.E852Q	TCGA-XF-AAN5	BLCA	TCGA	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation altering degron motif	0.6744
p.E852Q	DO51945	BLCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation altering degron motif	0.6744
p.R791W	TCGA-ZF-A9RC	BLCA	TCGA	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.0556
p.R791W	DO219068	BLCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.0556
p.R791W	DO228299	LICA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.0556
p.K666N	DO8264	COAD	ICGC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation altering degron motif	0.5806
p.A804T	DO222485	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.6028
p.R807H	DO229010	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.7133
p.R807H	DO229013	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.7133
p.R807H	DO229016	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.7133
p.R807H	DO229003	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.7133
p.R807H	DO229005	COCA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.7133
p.R807H	DO229489	LAML	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.7133
p.R807H	DO229053	LICA	ICGC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.7133
p.E852K	DO234201	ESAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation altering degron motif	0.7022
p.T850K	DO234379	ESAD	ICGC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation altering degron motif	0.7306
p.A853S	DO228985	LICA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.3056
p.A713S	DO229019	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1389
p.G714C	DO229015	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1667
p.S662I	DO229022	LICA	ICGC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.25
p.A670E	DO231837	LINC	ICGC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation altering degron motif	0.659
p.A720T	DO228338	MALY	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7139
p.A720T	SIDM00948	Burkitt's Lymphoma	GDSC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7139
p.A720T	DG-75	haematopoietic and lymphoid tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation altering degron motif	0.7139
p.L733F	DO218863	SKCA	ICGC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.0833
p.H860L	DO231393	THCA	ICGC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.1111
p.F711Y	SIDM00525	Osteosarcoma	GDSC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.0833
p.F711Y	ACH-000359	Bone Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.0833
p.F711Y	MG-63	bone	COSMIC	AKSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.0833
p.R856Q	SIDM00304	Ovarian Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.2222
p.G859R	SIDM00652	Small Cell Lung Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.1389
p.G859R	ACH-000780	Lung Cancer	CCLE	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.1389
p.G859R	NCI-H1105	lung	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.1389
p.R856W	SIDM00566	Oral Cavity Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.2222
p.R856W	SIDM00161	Biliary Tract Carcinoma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.2222
p.R856W	SIDM01574	Plasma Cell Myeloma	GDSC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.2222
p.R856W	OSC-19	upper aerodigestive tract	COSMIC	SSSTGE	DEG_Kelch_Keap1_1	847:852	Mutation rewiring degron network	0.2222
p.S662C	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.25
p.S662C	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.25
p.R798P	SIDM00273	Glioblastoma	GDSC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.25
p.R798P	ACH-000756	Brain Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.25
p.R798P	GI-1	central nervous system	COSMIC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.25
p.S808T	ACH-000621	Breast Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation altering degron motif	0.6005
p.H813P	ACH-000871	Lung Cancer	CCLE	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.3056
p.H813P	NCI-H510A	lung	COSMIC	LAPATERSSLSL	DEG_ODPH_VHL_1	801:812	Mutation rewiring degron network	0.3056
p.T675P	ACH-000993	Endometrial/Uterine Cancer	CCLE	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation blocking phosphorylation signal	0.6944
p.R657K	ACH-002396	Bone Cancer	CCLE	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.1111
p.R657K	Sarc9371	bone	COSMIC	PKITPAGT	DEG_SCF_FBW7_1	665:672	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF19

UniProt ID: Q2TAC6

Entrez ID: 124602

Protein name: Kinesin-like protein KIF19

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF19 in