DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AKSSS
Uniprot ID:
Q2TAC6
Source protein:
Kinesin-like protein KIF19
Source gene:
KIF19
Class:
DEG_SPOP_SBC_1
Location:
720:724
E3 ligase:
SPOP
DEGRON score:
0.9422
ASA_SCORE:
94.54
COIL:
0.9218
CONS_SCORE:
0.3198
DSS_SCORE:
0.5903
HELIX:
0.055
FCONS_SCORE:
0.8621
RIG_SCORE:
0.6455
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T715S
TCGA-AA-3864
COAD
TCGA
AKSSS
DEG_SPOP_SBC_1
0.1944
p.T715S
DO8490
COAD
ICGC
AKSSS
DEG_SPOP_SBC_1
0.1944
p.P729L
TCGA-CA-6718
COAD
TCGA
AKSSS
DEG_SPOP_SBC_1
0.1944
p.P729L
DO7801
COAD
ICGC
AKSSS
DEG_SPOP_SBC_1
0.1944
p.G716V
TCGA-ED-A459
LIHC
TCGA
AKSSS
DEG_SPOP_SBC_1
0.2222
p.G716V
DO44974
LIHC
ICGC
AKSSS
DEG_SPOP_SBC_1
0.2222
p.S723F
TCGA-EO-A3B0
UCEC
TCGA
AKSSS
DEG_SPOP_SBC_1
0.7982
p.S723F
DO222532
MELA
ICGC
AKSSS
DEG_SPOP_SBC_1
0.7982
p.S723F
DO219773
UCEC
ICGC
AKSSS
DEG_SPOP_SBC_1
0.7982
p.P730L
TCGA-EY-A1GO
UCEC
TCGA
AKSSS
DEG_SPOP_SBC_1
0.1667
p.P730L
DO41392
UCEC
ICGC
AKSSS
DEG_SPOP_SBC_1
0.1667
p.A717T
TCGA-FR-A726
SKCM
TCGA
AKSSS
DEG_SPOP_SBC_1
0.25
p.A717T
DO48665
SKCM
ICGC
AKSSS
DEG_SPOP_SBC_1
0.25
p.S722N
TCGA-VQ-A91D
STAD
TCGA
AKSSS
DEG_SPOP_SBC_1
0.7069
p.S722N
DO51783
STAD
ICGC
AKSSS
DEG_SPOP_SBC_1
0.7069
p.A713S
DO229019
LICA
ICGC
AKSSS
DEG_SPOP_SBC_1
0.1389
p.G714C
DO229015
LICA
ICGC
AKSSS
DEG_SPOP_SBC_1
0.1667
p.A720T
DO228338
MALY
ICGC
AKSSS
DEG_SPOP_SBC_1
0.7139
p.A720T
SIDM00948
Burkitt's Lymphoma
GDSC
AKSSS
DEG_SPOP_SBC_1
0.7139
p.A720T
DG-75
haematopoietic_and_lymphoid_tissue
COSMIC
AKSSS
DEG_SPOP_SBC_1
0.7139
p.L733F
DO218863
SKCA
ICGC
AKSSS
DEG_SPOP_SBC_1
0.0833
p.F711Y
SIDM00525
Osteosarcoma
GDSC
AKSSS
DEG_SPOP_SBC_1
0.0833
p.F711Y
ACH-000359
Bone Cancer
CCLE
AKSSS
DEG_SPOP_SBC_1
0.0833
p.F711Y
MG-63
bone
COSMIC
AKSSS
DEG_SPOP_SBC_1
0.0833
Drug responses associated with KIF19 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AKSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14647
Chromodomain-helicase-DNA-binding protein 2
DEG_SPOP_SBC_1
1432:1436
AKSSS
SPOP
0.9644
More...
O60885
Bromodomain-containing protein 4
DEG_SPOP_SBC_1
1217:1221
AKSSS
SPOP
0.9576
More...
O94762
ATP-dependent DNA helicase Q5
DEG_SPOP_SBC_1
732:736
AKSSS
SPOP
0.7563
More...
O95294
RasGAP-activating-like protein 1
DEG_SPOP_SBC_1
2:6
AKSSS
SPOP
0.7406
More...
P25440
Bromodomain-containing protein 2
DEG_SPOP_SBC_1
474:478
AKSSS
SPOP
0.6808
More...
Q14693
Phosphatidate phosphatase LPIN1
DEG_SPOP_SBC_1
282:286
AKSSS
SPOP
0.9674
More...
Q5VWN6
Protein TASOR 2
DEG_SPOP_SBC_1
1165:1169
AKSSS
SPOP
0.9726
More...
Q6P4R8
Nuclear factor related to kappa-B-binding protein
DEG_SPOP_SBC_1
755:759
AKSSS
SPOP
0.5292
More...
Q6PRD1
Probable G-protein coupled receptor 179
DEG_SPOP_SBC_1
906:910
AKSSS
SPOP
0.9545
More...
Q8NEY1
Neuron navigator 1
DEG_SPOP_SBC_1
677:681
AKSSS
SPOP
0.9854
More...
Q96PV6
Leukocyte receptor cluster member 8
DEG_SPOP_SBC_1
59:63
AKSSS
SPOP
0.9898
More...
Q9NWH9
SAFB-like transcription modulator
DEG_SPOP_SBC_1
351:355
AKSSS
SPOP
0.9894
More...
Q9NYV4
Cyclin-dependent kinase 12
DEG_SPOP_SBC_1
167:171
AKSSS
SPOP
0.989
More...
Q9P2N6
KAT8 regulatory NSL complex subunit 3
DEG_SPOP_SBC_1
698:702
AKSSS
SPOP
0.9382
More...
Q9Y692
Glucocorticoid modulatory element-binding protein 1
DEG_SPOP_SBC_1
455:459
AKSSS
SPOP
0.8751
More...
Q2TAC6
Kinesin-like protein KIF19
DEG_SPOP_SBC_1
720:724
AKSSS
SPOP
0.9422
More...
Q96BN6
Primary cilium assembly protein FAM149B1
DEG_SPOP_SBC_1
203:207
AKSSS
SPOP
0.9219
More...
Q5SYE7
NHS-like protein 1
DEG_SPOP_SBC_1
1146:1150
AKSSS
SPOP
0.9831
More...
Q6ZVL6
UPF0606 protein KIAA1549L
DEG_SPOP_SBC_1
676:680
AKSSS
SPOP
0.9984
More...
A6NCF6
Putative MAGE domain-containing protein MAGEA13P
DEG_SPOP_SBC_1
332:336
AKSSS
SPOP
0.9368
More...