DegronMD - Q6P4R8(NFRKB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I348M	TCGA-A5-A0G2	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.V883I	TCGA-AC-A8OQ	BRCA	TCGA	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.0833
p.T350M	TCGA-AX-A2HC	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556
p.S766L	TCGA-B5-A0JY	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	755:759	Mutation blocking phosphorylation signal	0.5833
p.S766L	DO51912	BLCA	ICGC	AKSSS	DEG_SPOP_SBC_1	755:759	Mutation blocking phosphorylation signal	0.5833
p.S766L	SIDM01164	Glioma	GDSC	AKSSS	DEG_SPOP_SBC_1	755:759	Mutation blocking phosphorylation signal	0.5833
p.S766L	SW1783	central nervous system	COSMIC	AKSSS	DEG_SPOP_SBC_1	755:759	Mutation blocking phosphorylation signal	0.5833
p.L333I	TCGA-B5-A1MX	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.25
p.P1185T	TCGA-ER-A19B	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0556
p.K338N	TCGA-ER-A19B	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.6918
p.V1163M	TCGA-EW-A1IZ	BRCA	TCGA	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.25
p.V1163M	TCGA-EW-A1IZ	BRCA	TCGA	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.1111
p.P747L	TCGA-FS-A1ZA	SKCM	TCGA	AKSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.1111
p.R677H	TCGA-XK-AAIW	PRAD	TCGA	VKSSS	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.0833
p.S900C	DO219068	BLCA	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.2222
p.E335K	DO223732	CESC	ICGC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.3056
p.P1046H	DO227802	COCA	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation rewiring degron network	0.1389
p.T1157A	DO222794	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.0833
p.Q348H	DO52456	COCA	ICGC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.I1184T	DO234269	ESAD	ICGC	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0833
p.T1169N	DO233878	GACA	ICGC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation altering degron motif	0.7055
p.A330T	DO11854	GBM	ICGC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1667
p.S1027T	DO44446	HNSC	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation blocking phosphorylation signal	0.6389
p.S1027T	DO44446	HNSC	ICGC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation blocking phosphorylation signal	0.6667
p.V1044M	DO52085	HNSC	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation rewiring degron network	0.1944
p.V1044M	DO52085	HNSC	ICGC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation rewiring degron network	0.0833
p.V1044M	DO222908	MELA	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation rewiring degron network	0.1944
p.V1044M	DO222908	MELA	ICGC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation rewiring degron network	0.0833
p.P1032L	DO22373	LGG	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation altering degron motif	0.6471
p.P1032L	DO22373	LGG	ICGC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation altering degron motif	0.6471
p.S1028P	DO22237	LGG	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation rewiring degron network	0.2222
p.S1028P	DO22237	LGG	ICGC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation rewiring degron network	0.25
p.T1161A	DO228546	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.1944
p.T1161A	DO228546	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0556
p.A1159D	DO228952	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.1389
p.T906K	DO229022	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.0556
p.A893D	DO229025	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation altering degron motif	0.6682
p.P892Q	DO229041	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation altering degron motif	0.7035
p.A344T	DO23468	LINC	ICGC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.A344T	DO42280	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.E331G	DO48721	LIRI	ICGC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1944
p.A1031S	DO24547	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation altering degron motif	0.7588
p.T1174P	DO45351	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation altering degron motif	0.7031
p.P902R	DO230530	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.1667
p.P902R	NMC-G1	central nervous system	COSMIC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.1667
p.P902R	KYSE-50	oesophagus	COSMIC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.1667
p.P902R	HLE	liver	COSMIC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.1667
p.P902R	NCC010	kidney	COSMIC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.1667
p.P902R	THP-1	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.1667
p.P902R	MFH-ino	soft tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.1667
p.T1161I	DO220898	MELA	ICGC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.1944
p.T1161I	DO220898	MELA	ICGC	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0556
p.T1161I	DO222420	MELA	ICGC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.1944
p.T1161I	DO222420	MELA	ICGC	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0556
p.G342K	DO222843	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2778
p.V761I	DO51476	PACA	ICGC	AKSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.2778
p.S896Y	DO36556	READ	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation altering degron motif	0.712
p.S896Y	DO41758	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation altering degron motif	0.712
p.P682A	DO229446	SKCA	ICGC	VKSSS	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.2222
p.P897S	DO229465	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.3056
p.P680L	DO37579	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.1667
p.P1160T	DO47491	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.1667
p.A901V	DO47389	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.1944
p.R1163W	DO42608	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.25
p.R1163W	DO42608	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.1111
p.K336N	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.6918
p.K336N	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.6918
p.A1049V	SIDM00007	Other Solid Cancers	GDSC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation blocking ubiquitination signal	0.5
p.A1049V	MCC13	skin	COSMIC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation blocking ubiquitination signal	0.5
p.K336R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.7237
p.A693T	SIDM00333	Endometrial Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.25
p.A693T	MFE-319	endometrium	COSMIC	VKSSS	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.25
p.H1043Y	SIDM00999	Bladder Carcinoma	GDSC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation substituting flanking lysine	0.3333
p.H1043Y	SIDM00999	Bladder Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation substituting flanking lysine	0.2222
p.H1043Y	639-V	urinary tract	COSMIC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation substituting flanking lysine	0.3333
p.H1043Y	639-V	urinary tract	COSMIC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation substituting flanking lysine	0.2222
p.M769I	ACH-000880	Gastric Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0556
p.M769I	AGS	stomach	COSMIC	AKSSS	DEG_SPOP_SBC_1	755:759	Mutation rewiring degron network	0.0556
p.V1162M	ACH-000938	Leukemia	CCLE	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.2222
p.V1162M	ACH-000938	Leukemia	CCLE	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0833
p.V1162M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	1166:1170	Mutation rewiring degron network	0.2222
p.V1162M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VVSTS	DEG_SPOP_SBC_1	1171:1175	Mutation rewiring degron network	0.0833
p.P883H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.0833
p.A1024V	ACH-001550	Skin Cancer	CCLE	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation rewiring degron network	0.1111
p.A1024V	ACH-001550	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation rewiring degron network	0.1389
p.A1024V	MCC13	skin	COSMIC	PSSTPTGT	DEG_SCF_FBW7_1	1032:1039	Mutation rewiring degron network	0.1111
p.A1024V	MCC13	skin	COSMIC	APSST	DEG_SPOP_SBC_1	1031:1035	Mutation rewiring degron network	0.1389
p.L882F	ACH-001568	Skin Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	892:896	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFRKB

UniProt ID: Q6P4R8

Entrez ID: 4798

Protein name: Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFRKB in