DegronMD

Uniprot ID: Q6P4R8

Source protein: Nuclear factor related to kappa-B-binding protein

Source gene: NFRKB

Class: DEG_SCF_FBW7_1

Location: 1032:1039

E3 ligase: FBXW7

DEGRON score: 0.9723

ASA_SCORE: 91.0625

COIL: 0.9403

CONS_SCORE: 0.4198

DSS_SCORE: 0.5297

HELIX: 0.012

FCONS_SCORE: 1.0996

RIG_SCORE: 0.5573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1046H	DO227802	COCA	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	0.1389
p.S1027T	DO44446	HNSC	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	0.6389
p.V1044M	DO52085	HNSC	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	0.1944
p.V1044M	DO222908	MELA	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	0.1944
p.P1032L	DO22373	LGG	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	0.6471
p.S1028P	DO22237	LGG	ICGC	PSSTPTGT	DEG_SCF_FBW7_1	0.2222
p.A1049V	SIDM00007	Other Solid Cancers	GDSC	PSSTPTGT	DEG_SCF_FBW7_1	0.5
p.A1049V	MCC13	skin	COSMIC	PSSTPTGT	DEG_SCF_FBW7_1	0.5
p.H1043Y	SIDM00999	Bladder Carcinoma	GDSC	PSSTPTGT	DEG_SCF_FBW7_1	0.3333
p.H1043Y	639-V	urinary_tract	COSMIC	PSSTPTGT	DEG_SCF_FBW7_1	0.3333
p.A1024V	ACH-001550	Skin Cancer	CCLE	PSSTPTGT	DEG_SCF_FBW7_1	0.1111
p.A1024V	MCC13	skin	COSMIC	PSSTPTGT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SCF_FBW7_1	1032:1039	PSSTPTGT	FBXW7	0.9723	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons