DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PVSTT
Uniprot ID:
Q6P4R8
Source protein:
Nuclear factor related to kappa-B-binding protein
Source gene:
NFRKB
Class:
DEG_SPOP_SBC_1
Location:
1166:1170
E3 ligase:
SPOP
DEGRON score:
0.9956
ASA_SCORE:
81.68
COIL:
0.7886
CONS_SCORE:
0.3952
DSS_SCORE:
0.3987
HELIX:
0.017
FCONS_SCORE:
0.9139
RIG_SCORE:
0.7831
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V1163M
TCGA-EW-A1IZ
BRCA
TCGA
PVSTT
DEG_SPOP_SBC_1
0.25
p.T1157A
DO222794
COCA
ICGC
PVSTT
DEG_SPOP_SBC_1
0.0833
p.T1169N
DO233878
GACA
ICGC
PVSTT
DEG_SPOP_SBC_1
0.7055
p.T1161A
DO228546
LICA
ICGC
PVSTT
DEG_SPOP_SBC_1
0.1944
p.A1159D
DO228952
LICA
ICGC
PVSTT
DEG_SPOP_SBC_1
0.1389
p.T1161I
DO220898
MELA
ICGC
PVSTT
DEG_SPOP_SBC_1
0.1944
p.T1161I
DO222420
MELA
ICGC
PVSTT
DEG_SPOP_SBC_1
0.1944
p.P1160T
DO47491
SKCM
ICGC
PVSTT
DEG_SPOP_SBC_1
0.1667
p.R1163W
DO42608
UCEC
ICGC
PVSTT
DEG_SPOP_SBC_1
0.25
p.V1162M
ACH-000938
Leukemia
CCLE
PVSTT
DEG_SPOP_SBC_1
0.2222
p.V1162M
NALM-6
haematopoietic_and_lymphoid_tissue
COSMIC
PVSTT
DEG_SPOP_SBC_1
0.2222
Drug responses associated with NFRKB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PVSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q685J3
Mucin-17
DEG_SPOP_SBC_1
458:462
PVSTT
SPOP
0.8219
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
1166:1170
PVSTT
SPOP
0.615
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
1284:1288
PVSTT
SPOP
0.7705
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
1402:1406
PVSTT
SPOP
0.678
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
1755:1759
PVSTT
SPOP
0.7406
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
1932:1936
PVSTT
SPOP
0.9647
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2050:2054
PVSTT
SPOP
0.8263
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2167:2171
PVSTT
SPOP
0.6746
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2344:2348
PVSTT
SPOP
0.9456
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2462:2466
PVSTT
SPOP
0.5519
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2521:2525
PVSTT
SPOP
0.799
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3052:3056
PVSTT
SPOP
0.791
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3111:3115
PVSTT
SPOP
0.5181
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3287:3291
PVSTT
SPOP
0.9282
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3523:3527
PVSTT
SPOP
0.8654
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3641:3645
PVSTT
SPOP
0.6776
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3700:3704
PVSTT
SPOP
0.7947
More...
Q6P4R8
Nuclear factor related to kappa-B-binding protein
DEG_SPOP_SBC_1
1166:1170
PVSTT
SPOP
0.9956
More...
Q6ZSZ6
Teashirt homolog 1
DEG_SPOP_SBC_1
164:168
PVSTT
SPOP
0.8971
More...
Q8IWK6
Adhesion G protein-coupled receptor A3
DEG_SPOP_SBC_1
1256:1260
PVSTT
SPOP
0.997
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
7701:7705
PVSTT
SPOP
0.9414
More...
Q96RL7
Intermembrane lipid transfer protein VPS13A
DEG_SPOP_SBC_1
1023:1027
PVSTT
SPOP
0.8888
More...
Q99700
Ataxin-2
DEG_SPOP_SBC_1
1290:1294
PVSTT
SPOP
0.9197
More...
Q9H4A3
Serine/threonine-protein kinase WNK1
DEG_SPOP_SBC_1
1737:1741
PVSTT
SPOP
0.9631
More...
O15034
RIMS-binding protein 2
DEG_SPOP_SBC_1
663:667
PVSTT
SPOP
0.6642
More...
Q9P206
Uncharacterized protein KIAA1522
DEG_SPOP_SBC_1
637:641
PVSTT
SPOP
0.942
More...