DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3287:3291

E3 ligase: SPOP

DEGRON score: 0.9282

ASA_SCORE: 88.84

COIL: 0.83

CONS_SCORE: 0.5236

DSS_SCORE: 0.6438

HELIX: 0.0142

FCONS_SCORE: 1

RIG_SCORE: 0.6808

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3291I	TCGA-50-5935	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7078
p.T3291I	DO23588	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7078
p.S3277C	TCGA-69-8255	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S3277C	DO25360	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.V3293L	TCGA-AR-A1AO	BRCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2778
p.V3293L	DO4443	BRCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.G3279R	TCGA-BF-A1PV	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G3279R	DO47309	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.T3292M	TCGA-BR-8591	STAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.3056
p.T3292M	DO47973	STAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.T3292M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.T3292M	ACH-000922	Leukemia	CCLE	PVSTT	DEG_SPOP_SBC_1	0.3056
p.T3292M	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.S3299G	TCGA-E7-A4IJ	BLCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S3299G	DO453	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S3285T	TCGA-LN-A7HV	ESCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S3299N	DO224754	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S3299N	DO229013	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S3299N	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.S3299N	DO52365	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.T3300S	DO224754	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.S3285G	DO229013	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S3285G	DO229016	COCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.S3285G	DO52365	LUSC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.2778
p.E3278D	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E3278D	ACH-000789	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E3278D	NCI-H810	lung	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.T3284I	SIDM00221	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.25
p.M3286V	SIDM01182	Bladder Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.M3286V	ACH-000522	Bladder Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.3056
p.M3286V	UM-UC-3	urinary_tract	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.S3277I	SIDM00097	Breast Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S3277I	ACH-000147	Breast Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S3277I	T47D	breast	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.V3288A	SIDM00217	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.5825
p.V3288A	SNU-1040	large_intestine	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...