DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3700:3704

E3 ligase: SPOP

DEGRON score: 0.7947

ASA_SCORE: 87.92

COIL: 0.857

CONS_SCORE: 0.5236

DSS_SCORE: 0.634

HELIX: 0.0136

FCONS_SCORE: 1

RIG_SCORE: 0.7386

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3690N	TCGA-36-2534	OV	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0556
p.S3690N	DO29046	OV	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.P3700L	TCGA-D1-A16X	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7582
p.P3700L	DO41799	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7582
p.S3709F	TCGA-DA-A1HV	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.S3709F	DO37659	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.G3692E	TCGA-FR-A726	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1111
p.G3692E	DO48665	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.E3710K	TCGA-FS-A1ZW	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E3710K	DO37519	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.P3695S	TCGA-GF-A6C8	SKCM	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3695S	DO48765	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.R3705C	TCGA-XK-AAIW	PRAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705C	DO223416	CLLE	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705C	DO51407	PRAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705C	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705C	SIDM01434	Hepatocellular Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705C	ACH-000316	Liver Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705C	ACH-000995	Leukemia	CCLE	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705C	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.R3705H	DO50362	ESAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056
p.T3694A	DO233652	GACA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.G3692V	DO229035	LICA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1111
p.E3691K	SIDM00336	Melanoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E3691K	ACH-000881	Skin Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E3691K	MEL-JUSO	skin	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.P3695L	SIDM00290	Gastric Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3695L	SIDM00214	Colorectal Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3695L	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3695L	SIDM01463	Endometrial Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.P3695L	SNU-407	large_intestine	COSMIC	PVSTT	DEG_SPOP_SBC_1	0.1944
p.S3693I	SIDM00368	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	0.1389
p.S3693I	ACH-000670	Lung Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1389
p.S3712I	ACH-001685	Lymphoma	CCLE	PVSTT	DEG_SPOP_SBC_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...