DegronMD - Q99700(ATXN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1298H	TCGA-28-5211	GBM	TCGA	PVSTT	DEG_SPOP_SBC_1	1290:1294	Mutation rewiring degron network	0.2222
p.P1298H	DO11016	GBM	ICGC	PVSTT	DEG_SPOP_SBC_1	1290:1294	Mutation rewiring degron network	0.2222
p.D898Y	TCGA-66-2759	LUSC	TCGA	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.0833
p.H951Y	TCGA-69-7979	LUAD	TCGA	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.25
p.T881N	TCGA-78-7539	LUAD	TCGA	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.2222
p.K821N	TCGA-A5-A0G2	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation blocking ubiquitination signal	0.5278
p.E764D	TCGA-AX-A1CE	UCEC	TCGA	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6758
p.A739D	TCGA-AX-A1CE	UCEC	TCGA	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation rewiring degron network	0.3056
p.K799E	TCGA-B5-A1MR	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation substituting flanking lysine	0.1944
p.T730M	TCGA-BG-A0M7	UCEC	TCGA	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation blocking phosphorylation signal	0.5
p.A1029G	TCGA-BQ-7059	KIRP	TCGA	PPAY	ITCH	1031:1034	Mutation rewiring degron network	0.2778
p.Q886E	TCGA-BT-A3PH	BLCA	TCGA	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation altering degron motif	0.5633
p.A732D	TCGA-CR-6491	HNSC	TCGA	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation rewiring degron network	0.1111
p.Y958H	TCGA-DI-A1BU	UCEC	TCGA	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation altering degron motif	0.6118
p.S776L	TCGA-EK-A3GK	CESC	TCGA	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation blocking phosphorylation signal	0.5
p.V962A	TCGA-EO-A22R	UCEC	TCGA	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.25
p.V962A	DO50327	ESAD	ICGC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.25
p.S814Y	TCGA-EO-A22R	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation blocking phosphorylation signal	0.7222
p.A1280T	TCGA-EO-A22X	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	1290:1294	Mutation rewiring degron network	0.0556
p.A1295V	TCGA-EO-A3KU	UCEC	TCGA	PVSTT	DEG_SPOP_SBC_1	1290:1294	Mutation rewiring degron network	0.3056
p.K763N	TCGA-F5-6814	READ	TCGA	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6918
p.T1036M	TCGA-HU-A4H0	STAD	TCGA	PPAY	ITCH	1031:1034	Mutation rewiring degron network	0.2778
p.S809T	TCGA-L5-A4OI	ESCA	TCGA	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.6005
p.G232E	DO225163	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0833
p.R812K	DO3110	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.7237
p.S946C	DO49976	CESC	ICGC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1111
p.A820T	DO9010	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1111
p.A820T	DO38551	STAD	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1111
p.M740V	DO8224	COAD	ICGC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation altering degron motif	0.7208
p.V806L	DO227976	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.2778
p.S751T	DO234206	ESAD	ICGC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation rewiring degron network	0.1667
p.A224P	DO233952	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1667
p.A224P	DO233952	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.3056
p.H966Y	DO14526	HNSC	ICGC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1389
p.H966Y	DO37707	SKCM	ICGC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1389
p.P944S	DO52073	HNSC	ICGC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.0556
p.H966Q	DO16248	KIRC	ICGC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1389
p.A766G	DO20932	KIRP	ICGC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.754
p.H219Q	DO228971	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.7582
p.H883N	DO228985	LICA	ICGC	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.2778
p.T891N	DO229022	LICA	ICGC	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.2778
p.T891N	DO229031	LICA	ICGC	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.2778
p.A815E	DO229022	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.25
p.A815E	DO229027	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.25
p.P768Q	DO229027	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation rewiring degron network	0.2778
p.T773K	DO229026	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation rewiring degron network	0.1389
p.S213Y	DO229031	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.3056
p.S213Y	DO229031	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1667
p.N947K	DO229031	LICA	ICGC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1389
p.Q1043K	DO229006	LICA	ICGC	PPAY	ITCH	1031:1034	Mutation rewiring degron network	0.0833
p.N222K	DO229006	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.6918
p.H819Q	DO23474	LINC	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1389
p.H969Q	DO23996	LUAD	ICGC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.0556
p.H799R	DO30980	OV	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation substituting flanking lysine	0.1944
p.I229S	DO51487	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1667
p.S220N	DO228138	PBCA	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.5958
p.V802I	DO232224	PBCA	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1667
p.H801Y	DO48546	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation substituting flanking lysine	0.25
p.G899C	DO37703	SKCM	ICGC	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation substituting flanking lysine	0.1667
p.P879Q	DO38016	SKCM	ICGC	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1667
p.P230S	DO51232	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1389
p.T773M	DO47785	STAD	ICGC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation rewiring degron network	0.1389
p.K227N	DO219773	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.0833
p.K227N	DO219773	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.2222
p.K736T	DO40884	UCEC	ICGC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation blocking phosphorylation signal	0.6667
p.A1032V	DO50079	UCEC	ICGC	PPAY	ITCH	1031:1034	Mutation altering degron motif	0.6936
p.R224M	DO41235	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1667
p.R224M	DO41235	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.3056
p.H219P	DO41379	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.7694
p.N762I	SIDM01034	B-Lymphoblastic Leukemia	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.N762I	SIDM00585	Hepatocellular Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.N762I	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.N762I	SIDM00316	Glioblastoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.N762I	SIDM01394	Kidney Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.N762I	YH-13	central nervous system	COSMIC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.N762I	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.N762I	HuH-7	liver	COSMIC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.N762I	TE-15	oesophagus	COSMIC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.6169
p.A209T	SIDM00499	Prostate Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1944
p.A209T	SIDM00499	Prostate Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0556
p.I766V	SIDM00845	Burkitt's Lymphoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.5965
p.N762S	SIDM00845	Burkitt's Lymphoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.5958
p.P954S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation altering degron motif	0.6752
p.P954S	SIDM00920	Breast Carcinoma	GDSC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation altering degron motif	0.6752
p.P954S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation altering degron motif	0.6752
p.M968I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.0833
p.M968I	NCI-H1155	lung	COSMIC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.0833
p.K763E	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.7022
p.K763E	NCI-H650	lung	COSMIC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation altering degron motif	0.7022
p.R755M	SIDM00214	Colorectal Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation rewiring degron network	0.1389
p.R755M	SIDM00214	Colorectal Carcinoma	GDSC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation rewiring degron network	0.0556
p.R755M	SNU-407	large intestine	COSMIC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation rewiring degron network	0.1389
p.R755M	SNU-407	large intestine	COSMIC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation rewiring degron network	0.0556
p.V740F	SIDM00233	T-Lymphoblastic Leukemia	GDSC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation altering degron motif	0.7068
p.V740F	ATN-1	haematopoietic and lymphoid tissue	COSMIC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation altering degron motif	0.7068
p.P773H	SIDM01612	Endometrial Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation rewiring degron network	0.1389
p.R216C	ACH-000922	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation altering degron motif	0.8301
p.R216C	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation altering degron motif	0.8301
p.A209S	ACH-000944	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1944
p.A209S	ACH-000944	Lymphoma	CCLE	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0556
p.T1301M	ACH-000966	Ovarian Cancer	CCLE	PVSTT	DEG_SPOP_SBC_1	1290:1294	Mutation rewiring degron network	0.1389
p.S220F	ACH-000984	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.6871
p.A818T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1667
p.H1026Y	NCI-H1563	lung	COSMIC	PPAY	ITCH	1031:1034	Mutation rewiring degron network	0.1944
p.T774A	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	NKENI	DEG_APCC_KENBOX_2	762:766	Mutation blocking phosphorylation signal	0.5556
p.L891P	NCI-H508	large intestine	COSMIC	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.2778
p.V968L	H513	pleura	COSMIC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.0833
p.Q229H	SKN	soft tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1667
p.A745T	SNU-1040	large intestine	COSMIC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation altering degron motif	0.7139
p.M808I	NCI-H1155	lung	COSMIC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation altering degron motif	0.7618
p.S815N	MN-60	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.25
p.P820H	HCC1569	breast	COSMIC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1111
p.L875V	RKO	large intestine	COSMIC	VQTSS	DEG_SPOP_SBC_1	885:889	Mutation substituting flanking lysine	0.1667
p.K209N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1944
p.K209N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0556
p.T819M	GP5d	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	808:812	Mutation rewiring degron network	0.1389
p.L1022V	RKO	large intestine	COSMIC	PPAY	ITCH	1031:1034	Mutation rewiring degron network	0.0833
p.L1035V	RKO	large intestine	COSMIC	PPAY	ITCH	1031:1034	Mutation rewiring degron network	0.3056
p.T966M	GP5d	large intestine	COSMIC	PTPVYT	DEG_SCF_FBW7_1	954:959	Mutation rewiring degron network	0.1389
p.S232L	SK-MEL-30	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0833
p.L1038P	NCI-H508	large intestine	COSMIC	PPAY	ITCH	1031:1034	Mutation rewiring degron network	0.2222
p.P230H	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.1389
p.M738I	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VTPSSE	DEG_SCF_FBW7_2	740:745	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN2

UniProt ID: Q99700

Entrez ID: 6311

Protein name: Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATXN2 in