DegronMD

Uniprot ID: Q99700

Source protein: Ataxin-2

Source gene: ATXN2

Class: DEG_SPOP_SBC_1

Location: 885:889

E3 ligase: SPOP

DEGRON score: 0.9482

ASA_SCORE: 84

COIL: 0.8954

CONS_SCORE: 0.328

DSS_SCORE: 0.6931

HELIX: 0.0192

FCONS_SCORE: 1.1466

RIG_SCORE: 0.6148

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D898Y	TCGA-66-2759	LUSC	TCGA	VQTSS	DEG_SPOP_SBC_1	0.0833
p.T881N	TCGA-78-7539	LUAD	TCGA	VQTSS	DEG_SPOP_SBC_1	0.2222
p.Q886E	TCGA-BT-A3PH	BLCA	TCGA	VQTSS	DEG_SPOP_SBC_1	0.5633
p.H883N	DO228985	LICA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2778
p.T891N	DO229022	LICA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2778
p.T891N	DO229031	LICA	ICGC	VQTSS	DEG_SPOP_SBC_1	0.2778
p.G899C	DO37703	SKCM	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1667
p.P879Q	DO38016	SKCM	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1667
p.L891P	NCI-H508	large_intestine	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.2778
p.L875V	RKO	large_intestine	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDB9	Paralemmin-3	DEG_SPOP_SBC_1	299:303	VQTSS	SPOP	0.9963	More...
O95201	Zinc finger protein 205	DEG_SPOP_SBC_1	207:211	VQTSS	SPOP	0.9657	More...
P23381	Tryptophan--tRNA ligase, cytoplasmic	DEG_SPOP_SBC_1	90:94	VQTSS	SPOP	0.8229	More...
Q96LL4	Uncharacterized protein C8orf48	DEG_SPOP_SBC_1	32:36	VQTSS	SPOP	0.9889	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	885:889	VQTSS	SPOP	0.9482	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	112:116	VQTSS	SPOP	0.9356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons