DegronMD

Uniprot ID: Q8WZ64

Source protein: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Source gene: ARAP2

Class: DEG_SPOP_SBC_1

Location: 112:116

E3 ligase: SPOP

DEGRON score: 0.9356

ASA_SCORE: 84.18

COIL: 0.9052

CONS_SCORE: 0.3444

DSS_SCORE: 0.6124

HELIX: 0.039

FCONS_SCORE: 1.0737

RIG_SCORE: 0.6122

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K125Q	TCGA-AX-A05Z	UCEC	TCGA	VQTSS	DEG_SPOP_SBC_1	0.1944
p.K125Q	DO40884	UCEC	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1944
p.S107F	TCGA-D3-A8GM	SKCM	TCGA	VQTSS	DEG_SPOP_SBC_1	0.1944
p.S107F	DO50288	SKCM	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1944
p.L106H	TCGA-HB-A3L4	SARC	TCGA	VQTSS	DEG_SPOP_SBC_1	0.1667
p.L106H	DO220134	SARC	ICGC	VQTSS	DEG_SPOP_SBC_1	0.1667
p.S116R	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00386	Ewing's Sarcoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00919	Ovarian Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00481	Ovarian Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00230	Small Cell Lung Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00285	Neuroblastoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00778	Colorectal Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM01088	Endometrial Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00003	Melanoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00814	Other Solid Cancers	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00063	Melanoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM01159	Other Sarcomas	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S116R	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.7427
p.S111G	SIDM00491	Thyroid Gland Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.3056
p.S111G	ACH-001443	Thyroid Cancer	CCLE	VQTSS	DEG_SPOP_SBC_1	0.3056
p.S111G	ASH-3	thyroid	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.3056
p.L106I	SIDM01504	Small Cell Lung Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	0.1667
p.L106I	ACH-000594	Lung Cancer	CCLE	VQTSS	DEG_SPOP_SBC_1	0.1667
p.G117W	NCI-H1648	lung	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.3056
p.Y110F	SK-MEL-30	skin	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.2778
p.H106Y	OC-314	ovary	COSMIC	VQTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDB9	Paralemmin-3	DEG_SPOP_SBC_1	299:303	VQTSS	SPOP	0.9963	More...
O95201	Zinc finger protein 205	DEG_SPOP_SBC_1	207:211	VQTSS	SPOP	0.9657	More...
P23381	Tryptophan--tRNA ligase, cytoplasmic	DEG_SPOP_SBC_1	90:94	VQTSS	SPOP	0.8229	More...
Q96LL4	Uncharacterized protein C8orf48	DEG_SPOP_SBC_1	32:36	VQTSS	SPOP	0.9889	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	885:889	VQTSS	SPOP	0.9482	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	112:116	VQTSS	SPOP	0.9356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQTSS

Degron related mutations and impact score

Drug responses associated with ARAP2 mutations

All proteins holding degron of VQTSS