DegronMD - Q8WZ64(ARAP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V446I	TCGA-19-5956	GBM	TCGA	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.V446I	DO13863	GBM	ICGC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.V446I	SIDM01117	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.V446I	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.V446I	SIDM00150	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1667
p.S302I	TCGA-49-AARE	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	310:314	Mutation blocking phosphorylation signal	0.5556
p.S302I	DO218922	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	310:314	Mutation blocking phosphorylation signal	0.5556
p.L343P	TCGA-85-A50Z	LUSC	TCGA	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1389
p.L343P	DO45462	LUSC	ICGC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1389
p.E336D	TCGA-A5-A0G2	UCEC	TCGA	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation altering degron motif	0.5647
p.E336D	DO41235	UCEC	ICGC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation altering degron motif	0.5647
p.E326D	TCGA-AG-A002	READ	TCGA	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1944
p.E326D	TCGA-AN-A046	BRCA	TCGA	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1944
p.E326D	DO1285	BRCA	ICGC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1944
p.E326D	SIDM00118	Colorectal Carcinoma	GDSC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1944
p.E326D	ACH-001081	Colon/Colorectal Cancer	CCLE	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1944
p.E326D	HCC2998	large intestine	COSMIC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1944
p.R305H	TCGA-AJ-A8CT	UCEC	TCGA	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.R305H	DO52399	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.K125Q	TCGA-AX-A05Z	UCEC	TCGA	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation substituting flanking lysine	0.1944
p.K125Q	DO40884	UCEC	ICGC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation substituting flanking lysine	0.1944
p.S107F	TCGA-D3-A8GM	SKCM	TCGA	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1944
p.S107F	DO50288	SKCM	ICGC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1944
p.N309Y	TCGA-DD-A116	LIHC	TCGA	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.R305C	TCGA-EE-A20C	SKCM	TCGA	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.R305C	DO222775	MELA	ICGC	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.R305C	DO47665	SKCM	ICGC	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.R305C	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.R305C	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.R305C	ACH-000066	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.R305C	ACH-000300	Kidney Cancer	CCLE	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.R305C	ACH-000960	Leukemia	CCLE	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.1944
p.V465I	TCGA-FU-A3HZ	CESC	TCGA	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0833
p.V465I	DO6308	CESC	ICGC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0833
p.L106H	TCGA-HB-A3L4	SARC	TCGA	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1667
p.L106H	DO220134	SARC	ICGC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1667
p.P333S	TCGA-QQ-A5VD	SARC	TCGA	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation altering degron motif	0.6752
p.P333S	TCGA-YD-A9TA	SKCM	TCGA	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation altering degron motif	0.6752
p.P333S	DO220252	SARC	ICGC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation altering degron motif	0.6752
p.P333S	DO219503	SKCM	ICGC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation altering degron motif	0.6752
p.S445C	TCGA-WE-A8K4	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.S445C	DO51281	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.K316Q	DO222884	COCA	ICGC	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.A460D	DO229019	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.S328L	DO222868	MELA	ICGC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.25
p.E315K	DO222875	MELA	ICGC	VATST	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.S116R	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00386	Ewing's Sarcoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00919	Ovarian Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00481	Ovarian Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00230	Small Cell Lung Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00285	Neuroblastoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00778	Colorectal Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM01088	Endometrial Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00003	Melanoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00814	Other Solid Cancers	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00063	Melanoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM01159	Other Sarcomas	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.S116R	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.7427
p.R448M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.R448M	ACH-000924	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.R448M	NCI-H2172	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.S111G	SIDM00491	Thyroid Gland Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.S111G	ACH-001443	Thyroid Cancer	CCLE	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.S111G	ASH-3	thyroid	COSMIC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.I442N	SIDM00488	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.I442N	SIDM00008	Ovarian Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.I442N	SIDM01619	Endometrial Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.I442N	ACH-000796	Ovarian Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.I442N	ACH-000984	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.I442N	ACH-001513	Cervical Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.I442N	ACH-002345	Colon/Colorectal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.0556
p.L106I	SIDM01504	Small Cell Lung Carcinoma	GDSC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1667
p.L106I	ACH-000594	Lung Cancer	CCLE	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1667
p.D444Y	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1111
p.D444Y	ACH-000158	Lymphoma	CCLE	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1111
p.L343V	SIDM01443	Gastric Carcinoma	GDSC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1389
p.L343V	ACH-000344	Gastric Cancer	CCLE	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1389
p.S445F	ACH-002396	Bone Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.S445F	Sarc9371	bone	COSMIC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.D454N	639-V	urinary tract	COSMIC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.6932
p.T445M	VM-CUB-1	urinary tract	COSMIC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.G117W	NCI-H1648	lung	COSMIC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.G346R	FU-OV-1	ovary	COSMIC	IFPYGE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0556
p.T461I	NCI-H1793	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1944
p.Y110F	SK-MEL-30	skin	COSMIC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778
p.H106Y	OC-314	ovary	COSMIC	VQTSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARAP2

UniProt ID: Q8WZ64

Entrez ID: 116984

Protein name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARAP2 in