DegronMD

Uniprot ID: Q8WZ64

Source protein: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Source gene: ARAP2

Class: LIG_APCC_ABBA_1

Location: 331:336

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9553

ASA_SCORE: 54

COIL: 0.7213

CONS_SCORE: 0.4675

DSS_SCORE: 0.3449

HELIX: 0.128

FCONS_SCORE: 1.338

RIG_SCORE: 0.7832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L343P	TCGA-85-A50Z	LUSC	TCGA	IFPYGE	LIG_APCC_ABBA_1	0.1389
p.L343P	DO45462	LUSC	ICGC	IFPYGE	LIG_APCC_ABBA_1	0.1389
p.E336D	TCGA-A5-A0G2	UCEC	TCGA	IFPYGE	LIG_APCC_ABBA_1	0.5647
p.E336D	DO41235	UCEC	ICGC	IFPYGE	LIG_APCC_ABBA_1	0.5647
p.E326D	TCGA-AG-A002	READ	TCGA	IFPYGE	LIG_APCC_ABBA_1	0.1944
p.E326D	TCGA-AN-A046	BRCA	TCGA	IFPYGE	LIG_APCC_ABBA_1	0.1944
p.E326D	DO1285	BRCA	ICGC	IFPYGE	LIG_APCC_ABBA_1	0.1944
p.E326D	SIDM00118	Colorectal Carcinoma	GDSC	IFPYGE	LIG_APCC_ABBA_1	0.1944
p.E326D	ACH-001081	Colon/Colorectal Cancer	CCLE	IFPYGE	LIG_APCC_ABBA_1	0.1944
p.E326D	HCC2998	large_intestine	COSMIC	IFPYGE	LIG_APCC_ABBA_1	0.1944
p.P333S	TCGA-QQ-A5VD	SARC	TCGA	IFPYGE	LIG_APCC_ABBA_1	0.6752
p.P333S	TCGA-YD-A9TA	SKCM	TCGA	IFPYGE	LIG_APCC_ABBA_1	0.6752
p.P333S	DO220252	SARC	ICGC	IFPYGE	LIG_APCC_ABBA_1	0.6752
p.P333S	DO219503	SKCM	ICGC	IFPYGE	LIG_APCC_ABBA_1	0.6752
p.S328L	DO222868	MELA	ICGC	IFPYGE	LIG_APCC_ABBA_1	0.25
p.L343V	SIDM01443	Gastric Carcinoma	GDSC	IFPYGE	LIG_APCC_ABBA_1	0.1389
p.L343V	ACH-000344	Gastric Cancer	CCLE	IFPYGE	LIG_APCC_ABBA_1	0.1389
p.G346R	FU-OV-1	ovary	COSMIC	IFPYGE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	LIG_APCC_ABBA_1	331:336	IFPYGE	APC,CDC20,FZR1	0.9553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons