DegronMD

Uniprot ID: Q8WZ64

Source protein: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Source gene: ARAP2

Class: DEG_SPOP_SBC_1

Location: 310:314

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 80.84

COIL: 0.916

CONS_SCORE: 0.3274

DSS_SCORE: 0.4008

HELIX: 0.0504

FCONS_SCORE: 1.0047

RIG_SCORE: 0.7341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S302I	TCGA-49-AARE	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	0.5556
p.S302I	DO218922	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	0.5556
p.R305H	TCGA-AJ-A8CT	UCEC	TCGA	VATST	DEG_SPOP_SBC_1	0.1944
p.R305H	DO52399	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	0.1944
p.N309Y	TCGA-DD-A116	LIHC	TCGA	VATST	DEG_SPOP_SBC_1	0.3056
p.R305C	TCGA-EE-A20C	SKCM	TCGA	VATST	DEG_SPOP_SBC_1	0.1944
p.R305C	DO222775	MELA	ICGC	VATST	DEG_SPOP_SBC_1	0.1944
p.R305C	DO47665	SKCM	ICGC	VATST	DEG_SPOP_SBC_1	0.1944
p.R305C	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	0.1944
p.R305C	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.1944
p.R305C	ACH-000066	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.1944
p.R305C	ACH-000300	Kidney Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.1944
p.R305C	ACH-000960	Leukemia	CCLE	VATST	DEG_SPOP_SBC_1	0.1944
p.K316Q	DO222884	COCA	ICGC	VATST	DEG_SPOP_SBC_1	0.2778
p.E315K	DO222875	MELA	ICGC	VATST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	134:138	VATST	SPOP	0.9934	More...
Q13105	Zinc finger and BTB domain-containing protein 17	DEG_SPOP_SBC_1	142:146	VATST	SPOP	0.6095	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	442:446	VATST	SPOP	0.9946	More...
Q5GH76	XK-related protein 4	DEG_SPOP_SBC_1	541:545	VATST	SPOP	0.7319	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1517:1521	VATST	SPOP	0.9996	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	519:523	VATST	SPOP	0.9773	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1122:1126	VATST	SPOP	0.879	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1386:1390	VATST	SPOP	0.9581	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1688:1692	VATST	SPOP	0.9913	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	310:314	VATST	SPOP	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons