DegronMD - Q92766(RREB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P509T	TCGA-14-1795	GBM	TCGA	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.P509T	DO13114	GBM	ICGC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.A533V	TCGA-38-4625	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.A533V	DO23952	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.0556
p.T517M	TCGA-56-6546	LUSC	TCGA	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.T517M	DO26542	LUSC	ICGC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.T523S	TCGA-78-8662	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.6005
p.T523S	DO45346	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	519:523	Mutation altering degron motif	0.6005
p.A1131S	TCGA-95-7562	LUAD	TCGA	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0833
p.A1131S	DO51196	LUAD	ICGC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0833
p.T1113A	TCGA-B5-A11Y	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1944
p.T1113A	DO40889	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1944
p.R516Q	TCGA-D5-6928	COAD	TCGA	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.R516Q	DO7776	COAD	ICGC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.R516Q	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.R516Q	ACH-000727	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.R516Q	NCI-H2066	lung	COSMIC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.R516L	TCGA-IB-7651	PAAD	TCGA	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.R516L	DO46657	PAAD	ICGC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.25
p.P1117T	DO225337	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.3056
p.P1117T	DO234197	ESAD	ICGC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.3056
p.T1116A	DO224989	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.2778
p.P525L	DO230346	COCA	ICGC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.P525L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.P525L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.P525L	ACH-000995	Leukemia	CCLE	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.P525L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2778
p.A1112T	DO233847	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.1667
p.A1115T	SIDM00376	B-Lymphoblastic Leukemia	GDSC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.25
p.A1115T	ACH-000156	Leukemia	CCLE	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.25
p.N529D	SIDM00238	Ovarian Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1667
p.N529D	ACH-000947	Ovarian Cancer	CCLE	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1667
p.N529D	OVK-18	ovary	COSMIC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1667
p.P1109S	SIDM00006	Other Solid Cancers	GDSC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0833
p.P1109S	ACH-001552	Skin Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0833
p.P1109S	MCC26	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0833
p.A1131T	SIDM00217	Colorectal Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0833
p.A1131T	ACH-000999	Colon/Colorectal Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.0833
p.P515Q	SIDM01617	Endometrial Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.P515Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.2222
p.G528R	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1944
p.E529K	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VATST	DEG_SPOP_SBC_1	519:523	Mutation rewiring degron network	0.1667

Kaplan plot for RREB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RREB1

UniProt ID: Q92766

Entrez ID: 6239

Protein name: Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RREB1 in