DegronMD

Uniprot ID: Q92766

Source protein: Ras-responsive element-binding protein 1

Source gene: RREB1

Class: DEG_SPOP_SBC_1

Location: 519:523

E3 ligase: SPOP

DEGRON score: 0.9773

ASA_SCORE: 61.44

COIL: 0.6954

CONS_SCORE: 0.3608

DSS_SCORE: 0.4895

HELIX: 0.009

FCONS_SCORE: 0.9052

RIG_SCORE: 0.6998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P509T	TCGA-14-1795	GBM	TCGA	VATST	DEG_SPOP_SBC_1	0.0556
p.P509T	DO13114	GBM	ICGC	VATST	DEG_SPOP_SBC_1	0.0556
p.A533V	TCGA-38-4625	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	0.0556
p.A533V	DO23952	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	0.0556
p.T517M	TCGA-56-6546	LUSC	TCGA	VATST	DEG_SPOP_SBC_1	0.2778
p.T517M	DO26542	LUSC	ICGC	VATST	DEG_SPOP_SBC_1	0.2778
p.T523S	TCGA-78-8662	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	0.6005
p.T523S	DO45346	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	0.6005
p.R516Q	TCGA-D5-6928	COAD	TCGA	VATST	DEG_SPOP_SBC_1	0.25
p.R516Q	DO7776	COAD	ICGC	VATST	DEG_SPOP_SBC_1	0.25
p.R516Q	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.25
p.R516Q	ACH-000727	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.25
p.R516Q	NCI-H2066	lung	COSMIC	VATST	DEG_SPOP_SBC_1	0.25
p.R516L	TCGA-IB-7651	PAAD	TCGA	VATST	DEG_SPOP_SBC_1	0.25
p.R516L	DO46657	PAAD	ICGC	VATST	DEG_SPOP_SBC_1	0.25
p.P525L	DO230346	COCA	ICGC	VATST	DEG_SPOP_SBC_1	0.2778
p.P525L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.P525L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.P525L	ACH-000995	Leukemia	CCLE	VATST	DEG_SPOP_SBC_1	0.2778
p.P525L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VATST	DEG_SPOP_SBC_1	0.2778
p.N529D	SIDM00238	Ovarian Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.1667
p.N529D	ACH-000947	Ovarian Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.1667
p.N529D	OVK-18	ovary	COSMIC	VATST	DEG_SPOP_SBC_1	0.1667
p.P515Q	SIDM01617	Endometrial Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2222
p.P515Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.2222
p.G528R	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VATST	DEG_SPOP_SBC_1	0.1944
p.E529K	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VATST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	134:138	VATST	SPOP	0.9934	More...
Q13105	Zinc finger and BTB domain-containing protein 17	DEG_SPOP_SBC_1	142:146	VATST	SPOP	0.6095	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	442:446	VATST	SPOP	0.9946	More...
Q5GH76	XK-related protein 4	DEG_SPOP_SBC_1	541:545	VATST	SPOP	0.7319	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1517:1521	VATST	SPOP	0.9996	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	519:523	VATST	SPOP	0.9773	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1122:1126	VATST	SPOP	0.879	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1386:1390	VATST	SPOP	0.9581	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1688:1692	VATST	SPOP	0.9913	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	310:314	VATST	SPOP	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VATST

Degron related mutations and impact score

Drug responses associated with RREB1 mutations

All proteins holding degron of VATST