DegronMD

Uniprot ID: Q13105

Source protein: Zinc finger and BTB domain-containing protein 17

Source gene: ZBTB17

Class: DEG_SPOP_SBC_1

Location: 142:146

E3 ligase: SPOP

DEGRON score: 0.6095

ASA_SCORE: 74.6

COIL: 0.4452

CONS_SCORE: 0.3368

DSS_SCORE: 0.631

HELIX: 0.541

FCONS_SCORE: 0.8584

RIG_SCORE: 0.7397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R155H	TCGA-BR-4184	STAD	TCGA	VATST	DEG_SPOP_SBC_1	0.0833
p.R155H	DO228138	PBCA	ICGC	VATST	DEG_SPOP_SBC_1	0.0833
p.R155H	DO38328	STAD	ICGC	VATST	DEG_SPOP_SBC_1	0.0833
p.D134N	TCGA-DU-6392	LGG	TCGA	VATST	DEG_SPOP_SBC_1	0.1111
p.D134N	DO22237	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.1111
p.S148N	TCGA-FI-A2D5	UCEC	TCGA	VATST	DEG_SPOP_SBC_1	0.2778
p.S148N	DO41331	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	0.2778
p.R155C	DO233088	GACA	ICGC	VATST	DEG_SPOP_SBC_1	0.0833
p.E139G	SIDM00663	Melanoma	GDSC	VATST	DEG_SPOP_SBC_1	0.25
p.E139G	ACH-000814	Skin Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.25
p.E139G	Hs939-T	skin	COSMIC	VATST	DEG_SPOP_SBC_1	0.25
p.E134K	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	VATST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	134:138	VATST	SPOP	0.9934	More...
Q13105	Zinc finger and BTB domain-containing protein 17	DEG_SPOP_SBC_1	142:146	VATST	SPOP	0.6095	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	442:446	VATST	SPOP	0.9946	More...
Q5GH76	XK-related protein 4	DEG_SPOP_SBC_1	541:545	VATST	SPOP	0.7319	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1517:1521	VATST	SPOP	0.9996	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	519:523	VATST	SPOP	0.9773	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1122:1126	VATST	SPOP	0.879	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1386:1390	VATST	SPOP	0.9581	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1688:1692	VATST	SPOP	0.9913	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	310:314	VATST	SPOP	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons