DegronMD

Uniprot ID: Q14157

Source protein: Ubiquitin-associated protein 2-like

Source gene: UBAP2L

Class: DEG_SPOP_SBC_1

Location: 442:446

E3 ligase: SPOP

DEGRON score: 0.9946

ASA_SCORE: 95.74

COIL: 0.9394

CONS_SCORE: 0.4862

DSS_SCORE: 0.6568

HELIX: 0.0286

FCONS_SCORE: 1.1978

RIG_SCORE: 0.6282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P452L	TCGA-A6-6781	COAD	TCGA	VATST	DEG_SPOP_SBC_1	0.1667
p.P452L	DO8447	COAD	ICGC	VATST	DEG_SPOP_SBC_1	0.1667
p.P452L	SIDM01005	Acute Myeloid Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	0.1667
p.P452L	ACH-000263	Leukemia	CCLE	VATST	DEG_SPOP_SBC_1	0.1667
p.P452L	ACH-001197	Lymphoma	CCLE	VATST	DEG_SPOP_SBC_1	0.1667
p.P452L	ACH-001551	Skin Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.1667
p.P452L	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	VATST	DEG_SPOP_SBC_1	0.1667
p.E437D	TCGA-BT-A20J	BLCA	TCGA	VATST	DEG_SPOP_SBC_1	0.1944
p.E437D	DO457	BLCA	ICGC	VATST	DEG_SPOP_SBC_1	0.1944
p.L435F	DO228693	GACA	ICGC	VATST	DEG_SPOP_SBC_1	0.1389
p.Q436P	DO229490	PRAD	ICGC	VATST	DEG_SPOP_SBC_1	0.1667
p.P445L	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	VATST	DEG_SPOP_SBC_1	0.7582
p.R432H	SNU-1040	large_intestine	COSMIC	VATST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	134:138	VATST	SPOP	0.9934	More...
Q13105	Zinc finger and BTB domain-containing protein 17	DEG_SPOP_SBC_1	142:146	VATST	SPOP	0.6095	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	442:446	VATST	SPOP	0.9946	More...
Q5GH76	XK-related protein 4	DEG_SPOP_SBC_1	541:545	VATST	SPOP	0.7319	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1517:1521	VATST	SPOP	0.9996	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	519:523	VATST	SPOP	0.9773	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1122:1126	VATST	SPOP	0.879	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1386:1390	VATST	SPOP	0.9581	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1688:1692	VATST	SPOP	0.9913	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	310:314	VATST	SPOP	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons