DegronMD - Q5GH76(XKR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R553H	TCGA-06-5408	GBM	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R553H	TCGA-MP-A4TH	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R553H	TCGA-ZG-A9LB	PRAD	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R553H	DO12862	GBM	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R553H	DO45389	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R553H	DO219428	PRAD	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.P531R	TCGA-33-AASD	LUSC	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.0556
p.P531R	DO219127	LUSC	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.0556
p.S550T	TCGA-64-5781	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1944
p.S550T	DO23740	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1944
p.V541M	TCGA-AJ-A8CT	UCEC	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7208
p.V541M	DO52399	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7208
p.V541M	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7208
p.V541M	SIDM01001	Breast Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7208
p.V541M	ACH-000258	Breast Cancer	CCLE	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7208
p.V541M	ACH-000980	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7208
p.V541M	DU-4475	breast	COSMIC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7208
p.V541M	NCI-H1155	lung	COSMIC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7208
p.A533T	TCGA-CM-6162	COAD	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.A533T	DO8479	COAD	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R553C	TCGA-CX-7086	HNSC	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R553C	DO15046	HNSC	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R553C	DO46788	PRAD	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.1111
p.R547P	TCGA-D3-A8GM	SKCM	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547P	DO50288	SKCM	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547Q	TCGA-DX-A8BN	SARC	TCGA	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547Q	DO227749	BRCA	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547Q	DO220053	SARC	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547Q	SIDM00945	Colorectal Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547Q	SIDM01503	Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547Q	ACH-000844	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547Q	ACH-000895	Colon/Colorectal Cancer	CCLE	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547Q	CL-34	large intestine	COSMIC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547W	DO234150	ESAD	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.R547W	SNU-1040	large intestine	COSMIC	VATST	DEG_SPOP_SBC_1	541:545	Mutation rewiring degron network	0.2778
p.V541L	DO228985	LICA	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.6765
p.V541L	DO229018	LICA	ICGC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.6765
p.T545I	SIDM00867	Glioblastoma	GDSC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7078
p.T545I	ACH-000863	Brain Cancer	CCLE	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7078
p.T545I	DBTRG-05MG	central nervous system	COSMIC	VATST	DEG_SPOP_SBC_1	541:545	Mutation altering degron motif	0.7078

Kaplan plot for XKR4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XKR4

UniProt ID: Q5GH76

Entrez ID: 114786

Protein name: XK-related protein 4 (hXKR4) [Cleaved into: XK-related protein 4, processed form]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XKR4 in