DegronMD

Uniprot ID: Q5GH76

Source protein: XK-related protein 4

Source gene: XKR4

Class: DEG_SPOP_SBC_1

Location: 541:545

E3 ligase: SPOP

DEGRON score: 0.7319

ASA_SCORE: 77.12

COIL: 0.796

CONS_SCORE: 0.2955

DSS_SCORE: 0.3912

HELIX: 0.1572

FCONS_SCORE: 0.9674

RIG_SCORE: 0.7617

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R553H	TCGA-06-5408	GBM	TCGA	VATST	DEG_SPOP_SBC_1	0.1111
p.R553H	TCGA-MP-A4TH	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	0.1111
p.R553H	TCGA-ZG-A9LB	PRAD	TCGA	VATST	DEG_SPOP_SBC_1	0.1111
p.R553H	DO12862	GBM	ICGC	VATST	DEG_SPOP_SBC_1	0.1111
p.R553H	DO45389	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	0.1111
p.R553H	DO219428	PRAD	ICGC	VATST	DEG_SPOP_SBC_1	0.1111
p.P531R	TCGA-33-AASD	LUSC	TCGA	VATST	DEG_SPOP_SBC_1	0.0556
p.P531R	DO219127	LUSC	ICGC	VATST	DEG_SPOP_SBC_1	0.0556
p.S550T	TCGA-64-5781	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	0.1944
p.S550T	DO23740	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	0.1944
p.V541M	TCGA-AJ-A8CT	UCEC	TCGA	VATST	DEG_SPOP_SBC_1	0.7208
p.V541M	DO52399	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	0.7208
p.V541M	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.7208
p.V541M	SIDM01001	Breast Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.7208
p.V541M	ACH-000258	Breast Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.7208
p.V541M	ACH-000980	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.7208
p.V541M	DU-4475	breast	COSMIC	VATST	DEG_SPOP_SBC_1	0.7208
p.V541M	NCI-H1155	lung	COSMIC	VATST	DEG_SPOP_SBC_1	0.7208
p.A533T	TCGA-CM-6162	COAD	TCGA	VATST	DEG_SPOP_SBC_1	0.1111
p.A533T	DO8479	COAD	ICGC	VATST	DEG_SPOP_SBC_1	0.1111
p.R553C	TCGA-CX-7086	HNSC	TCGA	VATST	DEG_SPOP_SBC_1	0.1111
p.R553C	DO15046	HNSC	ICGC	VATST	DEG_SPOP_SBC_1	0.1111
p.R553C	DO46788	PRAD	ICGC	VATST	DEG_SPOP_SBC_1	0.1111
p.R547P	TCGA-D3-A8GM	SKCM	TCGA	VATST	DEG_SPOP_SBC_1	0.2778
p.R547P	DO50288	SKCM	ICGC	VATST	DEG_SPOP_SBC_1	0.2778
p.R547Q	TCGA-DX-A8BN	SARC	TCGA	VATST	DEG_SPOP_SBC_1	0.2778
p.R547Q	DO227749	BRCA	ICGC	VATST	DEG_SPOP_SBC_1	0.2778
p.R547Q	DO220053	SARC	ICGC	VATST	DEG_SPOP_SBC_1	0.2778
p.R547Q	SIDM00945	Colorectal Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.R547Q	SIDM01503	Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.R547Q	ACH-000844	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.2778
p.R547Q	ACH-000895	Colon/Colorectal Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.2778
p.R547Q	CL-34	large_intestine	COSMIC	VATST	DEG_SPOP_SBC_1	0.2778
p.R547W	DO234150	ESAD	ICGC	VATST	DEG_SPOP_SBC_1	0.2778
p.R547W	SNU-1040	large_intestine	COSMIC	VATST	DEG_SPOP_SBC_1	0.2778
p.V541L	DO228985	LICA	ICGC	VATST	DEG_SPOP_SBC_1	0.6765
p.V541L	DO229018	LICA	ICGC	VATST	DEG_SPOP_SBC_1	0.6765
p.T545I	SIDM00867	Glioblastoma	GDSC	VATST	DEG_SPOP_SBC_1	0.7078
p.T545I	ACH-000863	Brain Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.7078
p.T545I	DBTRG-05MG	central_nervous_system	COSMIC	VATST	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	134:138	VATST	SPOP	0.9934	More...
Q13105	Zinc finger and BTB domain-containing protein 17	DEG_SPOP_SBC_1	142:146	VATST	SPOP	0.6095	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	442:446	VATST	SPOP	0.9946	More...
Q5GH76	XK-related protein 4	DEG_SPOP_SBC_1	541:545	VATST	SPOP	0.7319	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1517:1521	VATST	SPOP	0.9996	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	519:523	VATST	SPOP	0.9773	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1122:1126	VATST	SPOP	0.879	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1386:1390	VATST	SPOP	0.9581	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1688:1692	VATST	SPOP	0.9913	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	310:314	VATST	SPOP	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VATST

Degron related mutations and impact score

Drug responses associated with XKR4 mutations

All proteins holding degron of VATST