DegronMD

Uniprot ID: Q8NFC6

Source protein: Biorientation of chromosomes in cell division protein 1-like 1

Source gene: BOD1L1

Class: DEG_SPOP_SBC_1

Location: 1517:1521

E3 ligase: SPOP

DEGRON score: 0.9996

ASA_SCORE: 81.4

COIL: 0.816

CONS_SCORE: 0.5222

DSS_SCORE: 0.6458

HELIX: 0.0468

FCONS_SCORE: 1.2821

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1507I	TCGA-CK-6746	COAD	TCGA	VATST	DEG_SPOP_SBC_1	0.5
p.T1507I	DO7938	COAD	ICGC	VATST	DEG_SPOP_SBC_1	0.5
p.T1521A	TCGA-DI-A1BU	UCEC	TCGA	VATST	DEG_SPOP_SBC_1	0.7139
p.T1521A	DO42023	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	0.7139
p.A1512E	DO229038	LICA	ICGC	VATST	DEG_SPOP_SBC_1	0.1944
p.R1511I	DO35098	PACA	ICGC	VATST	DEG_SPOP_SBC_1	0.1667
p.T1515A	SIDM00212	Glioblastoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM00855	Other Sarcomas	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM00846	Cervical Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM00690	Head and Neck Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM01039	Other Solid Cancers	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM00346	Chronic Myelogenous Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM00493	Other Solid Cancers	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM00844	Burkitt's Lymphoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM00721	Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.T1515A	SIDM00628	Breast Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2778
p.D1525E	SIDM00208	Glioblastoma	GDSC	VATST	DEG_SPOP_SBC_1	0.2222
p.D1525E	D-502MG	central_nervous_system	COSMIC	VATST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	134:138	VATST	SPOP	0.9934	More...
Q13105	Zinc finger and BTB domain-containing protein 17	DEG_SPOP_SBC_1	142:146	VATST	SPOP	0.6095	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	442:446	VATST	SPOP	0.9946	More...
Q5GH76	XK-related protein 4	DEG_SPOP_SBC_1	541:545	VATST	SPOP	0.7319	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1517:1521	VATST	SPOP	0.9996	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	519:523	VATST	SPOP	0.9773	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1122:1126	VATST	SPOP	0.879	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1386:1390	VATST	SPOP	0.9581	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1688:1692	VATST	SPOP	0.9913	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	310:314	VATST	SPOP	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons