DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VATST
Uniprot ID:
O00592
Source protein:
Podocalyxin
Source gene:
PODXL
Class:
DEG_SPOP_SBC_1
Location:
134:138
E3 ligase:
SPOP
DEGRON score:
0.9934
ASA_SCORE:
84.88
COIL:
0.9158
CONS_SCORE:
0.4333
DSS_SCORE:
0.5916
HELIX:
0.0166
FCONS_SCORE:
1.2407
RIG_SCORE:
0.7305
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T128A
DO48368
BLCA
ICGC
VATST
DEG_SPOP_SBC_1
0.6111
p.K127N
TCGA-K7-A5RG
LIHC
TCGA
VATST
DEG_SPOP_SBC_1
0.25
p.A141D
DO229028
LICA
ICGC
VATST
DEG_SPOP_SBC_1
0.25
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Drug responses associated with PODXL mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VATST
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WZ64
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
DEG_SPOP_SBC_1
310:314
VATST
SPOP
0.9982
More...
Q8NFC6
Biorientation of chromosomes in cell division protein 1-like 1
DEG_SPOP_SBC_1
1517:1521
VATST
SPOP
0.9996
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
1688:1692
VATST
SPOP
0.9913
More...
O00592
Podocalyxin
DEG_SPOP_SBC_1
134:138
VATST
SPOP
0.9934
More...
Q96RK0
Protein capicua homolog
DEG_SPOP_SBC_1
1122:1126
VATST
SPOP
0.879
More...
Q92766
Ras-responsive element-binding protein 1
DEG_SPOP_SBC_1
519:523
VATST
SPOP
0.9773
More...
Q9H4A3
Serine/threonine-protein kinase WNK1
DEG_SPOP_SBC_1
1386:1390
VATST
SPOP
0.9581
More...
Q14157
Ubiquitin-associated protein 2-like
DEG_SPOP_SBC_1
442:446
VATST
SPOP
0.9946
More...
Q5GH76
XK-related protein 4
DEG_SPOP_SBC_1
541:545
VATST
SPOP
0.7319
More...
Q13105
Zinc finger and BTB domain-containing protein 17
DEG_SPOP_SBC_1
142:146
VATST
SPOP
0.6095
More...
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