DegronMD - Q96RK0(CIC)

FUNCTION: Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}.

GO - Biological processes (BP): brain development [GO:0007420]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]; social behavior [GO:0035176]

GO - Molecular function (MF): DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]

GO - Cellular component (CC): chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
PGSSS	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	331:335	More..
APSSS	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	531:535	More..
PASSS	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	539:543	More..
PVSST	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	678:682	More..
APTTS	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	857:861	More..
PGTST	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	868:872	More..
APTSS	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	1101:1105	More..
VATST	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	1122:1126	More..
PSSSS	DEG_SPOP_SBC_1	SPOP	Protein capicua homolog	1270:1274	More..

Showing 1 to 9 of 9 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S335F	TCGA-GN-A8LK	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.9093
p.S335F	DO51259	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.9093
p.R1124W	DO222490	BTCA	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO223732	CESC	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO48508	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO50211	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO50147	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO50252	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO22163	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO22199	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO22315	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO223698	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R1124W	DO44585	LGG	ICGC	VATST	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.8634
p.R333H	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.8244
p.S333N	DO232761	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	331:335	Mutation altering degron motif	0.818
p.S1104F	TCGA-EE-A181	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7982
p.S1103F	DO37444	SKCM	ICGC	APTSS	DEG_SPOP_SBC_1	1101:1105	Mutation altering degron motif	0.7982
p.P1270H	TCGA-G2-A2EJ	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	1270:1274	Mutation altering degron motif	0.7694
p.P1270H	DO554	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1270:1274	Mutation altering degron motif	0.7694
p.P857H	ACH-000907	Kidney Cancer	CCLE	APTTS	DEG_SPOP_SBC_1	857:861	Mutation altering degron motif	0.7694

Showing 1 to 20 of 166 entries

Previous1 2 3 4 5…9Next

Kaplan plot for CIC in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CIC

UniProt ID: Q96RK0

Entrez ID: 23152

Protein name: Protein capicua homolog

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CIC in